研究総説

Exploiting the Reversible Covalent Bonding of Boronic Acids: Recognition, Sensing, and Assembly.

Steven D Bull, Matthew G. Davidson, Jean M. H. van den Elsen, John S. Fossey , A. Toby A. Jenkins, Yun-Bao Jiang , Yuji Kubo , Frank Marken, Kazuo Sakurai, Jianzhang Zhao , and Tony D. James.

Accounts of chemical research.

Publication Date (Web): November 14, 2012  DOI: 10.1021/ar300130w

 

β-1,3-Glucan polysaccharides as novel one-dimensional hosts for DNA/RNA, conjugated polymers and nanoparticles

Kazuo Sakurai ,  Kazuya Uezu ,  Munenori Numata ,  Teruaki Hasegawa ,  Chun Li ,  Kenji Kaneko and Seiji Shinkai

Feature Article of Chem Comm 2005, 4383-4398

 

Characterizing PEG Chains Tethered onto Micelles and Liposomes Applied as
Drug Delivery Vehicles Using Scattering Techniques 

Shota Fujii,Mina Sakuragi,Kazuo Sakurai

ACS Symposium Series, Vol. 1271  

 

論文

櫻井 和朗 論文集リンク

2021年

 


Anticancer efficacy of cyclodextrin-based hyperbranched polymer nanoparticles containing alpha-mangostin

Van TH Doan, Shin Takano, Ngoc Anh T Doan, Phuong TM Nguyen, T Nguyen Van Anh, Huong TT Pham, Koji Nakazawa, Shota Fujii, Kazuo Sakurai

Polymer Journal

 

 


 

Enhanced in-vitro efficacy of antisense delivery by use of low-molecular weight polysaccharide/DNA complex.

Kazuki Sumiya, Hiroto Izumi, Shinichi Mochizuki, Kazuo Sakurai

Chemistry Letters

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Inflammogenic Effect of Polyacrylic Acid in Rat Lung Following Intratracheal Instillation

 

Chinatsu Nishida, Taisuke Tomonaga, Hiroto Izumi, Ke-Yong Wang, Toru Ishidao, Jun-ichi Takeshita, Ryohei Ono, Kazuki Sumiya, Shota Fujii, Shinichi Mochizuki, Kazuo Sakurai, Kei Yamasaki, Kazuhiro Yatera, Yasuo Morimoto


2020年

 

 


Phosphorylcholine-Grafted Molecular Bottlebrush–Doxorubicin Conjugates: High Structural Stability,Long Circulation in Blood, and Efficient Anticancer Activity

Shin Takano, Waliul Islam, Kohji Nakazawa, Hiroshi Maeda, Kazuo Sakurai, Shota Fujii

Biomacromolecules

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Oligo-DNA Stoichiometrically Binds β-1, 3-Glucan with the Best Fit Length

Kazuki Sumiya, Takuya Matsunaga, Motoko Tanaka, Shinichi Mochizuki, Kazuo Sakurai

Biomacromolecules

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Induction of Potent Cell Growth Inhibition by Schizophyllan/K-Ras Antisense Complex in Combination with Gemcitabine

S Sasaki, H Izumi, Y Morimoto, K Sakurai, S Mochizuki
Bioorganic & Medicinal Chemistry, 115668
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Characterizing an siRNA-Containing Lipid-Nanoparticle Prepared by a Microfluidic Reactor: Small-Angle X-ray Scattering and Cryotransmission Electron Microscopic Studies
Kenichi Aburai, Kentaro Hatanaka, Shin Takano, Shota Fujii, Kazuo Sakurai

Langmuir
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Scattering Form Factor of Block Copolymer Micelles with Corona Chains Discretely Distributed on the Core Surface

R Takahashi, S Fujii, I Akiba, K Sakurai

The Journal of Physical Chemistry B

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Synthesis and characterization of nanoemulsion-mediated core crosslinked nanoparticles, and in vivo pharmacokinetics depending on the structural characteristics
J Matsuno, T Kanamaru, K Arai, R Tanaka, JH Lee, R Takahashi, ...
Journal of Controlled Release
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Structural Polymorphism of Resorcinarene Assemblies
S Fujii, R Miyake, L Campo, JH Lee, R Takahashi, K Sakurai
Langmuir
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Cyclodextrin-based nanoparticles encapsulating α-mangostin and their drug release behavior: potential carriers of α-mangostin for cancer therapy

VTH Doan, JH Lee, R Takahashi, PTM Nguyen, TN Van Anh, HTT Pham, ...
Polymer Journal 52 (4), 457-466

Topical Therapy with Antisense Tumor Necrosis Factor Alpha Using Novel β-Glucan-Based Drug Delivery System Ameliorates Intestinal Inflammation
H Sakisaka, H Takedatsu, K Mitsuyama, S Mochizuki, K Sakurai, ...
International Journal of Molecular Sciences 21 (2), 683
ijms-21-00683-g001-550.jpg

Unraveling the kinetics of the structural development during polymerization-induced self-assembly: decoupling the polymerization and the micelle structure

R Takahashi, S Miwa, FH Sobotta, JH Lee, S Fujii, N Ohta, JC Brendel, ...
Polymer Chemistry 11 (8), 1514-1524
Graphical abstract: Unraveling the kinetics of the structural development during polymerization-induced self-assembly: decoupling the polymerization and the micelle structure

Unraveling Decisive Structural Parameters for the Self-Assembly of Supramolecular Polymer Bottlebrushes Based on Benzene Trisureas

FV Gruschwitz, MC Fu, T Klein, R Takahashi, T Higashihara, ...
Macromolecules

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Monodisperse Micelles with Aggregation Numbers Related to Platonic Solids

JH Lee, S Fujii, R Takahashi, K Sakurai
Macromolecular Rapid Communications, 2000227

Furry nanoparticles: synthesis and characterization of nanoemulsion-mediated core crosslinked nanoparticles and their robust stability in vivo

R Tanaka, K Arai, J Matsuno, M Soejima, JH Lee, R Takahashi, K Sakurai, ...
Polymer Chemistry 11 (27), 4408-4416
         Graphical abstract: Furry nanoparticles: synthesis and characterization of nanoemulsion-mediated core crosslinked nanoparticles and their robust stability in vivo

 

Enhanced Binding Constant of Cyclodextrin to Alpha-mangostin in Hyperbranched Polymers

DTH Van, DTN Anh, S Fujii, K Sakurai
Chemistry Letters 49 (X)

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Flower Necklaces of Controllable Length Formed From N-(2-Hydroxypropyl) Methacrylamide-Based Amphiphilic Statistical Copolymers

 

R Takahashi, K Doi, S Fujii, K Sakurai
Langmuir

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2019

 


 

 

Non-dependence of dodecamer structures on alkyl chain length in Platonic micelles

Masataka Araki, Shota Fujii,  Ji Ha Lee, Rintaro Takahashi and Kazuo Sakurai

Article in Soft Matter  in press

 

soft_matter_2019.jpg        non-dependence_of_dodecamer.jpg 


 

Dual and Multiple Stimuli-Responsive Platonic Micelles Bearing Disaccharides

Rika Miyake,Shota Fujii,JI Ha Lee,Rintaro Takahashi,Kazuo Sakurai

Article in Journal of Colloid and Interface Science volume 535 Pages 8-15

 

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A Discrete and Discontinuous Increase in the Micellar Aggregation Number: Effects of the Alkyl Chain Length on Platonic Micelles

Shota Fujii,Shimpei Yamada,Masataka Araki,Ji Ha Lee,Rintaro Takahashi,Kazuo Sakurai

Langmuir, 2019, 35 (8), pp 3156–3161

 

langmuir_2019.jpg          discrete_and_discontinuous.jpg


 

Tuning of the aggregation number of Platonic micelles with binary mixture of calix[4]arene surfactants

Ji Ha Lee,Shota Fujii,Rintaro Takahashi,Kazuo Sakurai

Article in Chemical Communications 55(9)  

 

tuning_of_the_aggregation_number.jpg


 

Monodisperse micelles composed of poly(ethylene glycol) attached surfactants: platonic nature in a macromolecular aggregate

Ji Ha Lee, Hayata Matsumoto, Shota Fujii, Rintaro Takahashi and Kazuo Sakurai

Article in Soft Matter, 2019

 

monodisperse_micelles.jpg


 

Encapsulation of Albumin in Organic Nanotube Channel: Structural Investigation by Small-Angle X-ray Scattering

Hiroki Kawauchi, Rintaro Takahashi, Naohiro Kameta, Shota fujii, Ji Ha Lee, Toshimi Shimizu and Kazuo Sakurai

Article in ACS Appl. Bio Mater. 2019, 2, 4, 1652-1659

 

encapsulation_of_albumin.jpg


 

Observing the Kinetic Pathway of Nanotube Formation from Bolaamphiphiles by Time-Resolved Small-Angle X-ray Scattering

Rintaro Takahashi, Hiroki Kawauchi, Naohiro Kameta, Ji Ha Lee, Shota Fujii, Toshimi Shimizu and Kazuo Sakurai

Article in J. Phys. Chem. B, 2019, 123, 19, 4340-4345

 

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Complex consisting of antisense DNA and β-glucan promotes internalization into cell through Dectin-1 and hybridizes with target mRNA in cytosol

Nobuaki Fujiwara, Hiroto Izumi, Yasuo Morimoto, Kazuo Sakurai and Shinichi Mochizuki

Article in Cancer Gene Therapy 26, 32–40 (2019)

 

 


 

Co-administration of combretastatin A4 nanoparticles and sorafenib for systemic therapy of hepatocellular carcinoma
Yalin Wang, Haiyang Yu, Dawei Zhang, Guanyi Wang, Wantong Song, Yingmin Liu, Sheng Ma, Zhaohui Tang, Ziling Liu, Kazuo Sakurai and Xuesi Chen
Article in Acta Biomaterialia Vol 92 Pages 229-240


 

Structural analysis of a calix[4]arene-based Platonic Micelle
Efsta Mylonas, Naoto Yagi, Shota Fujii, Koudai Ikesue, Tomoya Ueda, Hideaki Moriyama, Yusuke Sanada, Kazuya Uezu, Kazuo Sakurai and Tadashi Okobira
Article in Scientific Reports 9 Article number 1982 (2019)

 


 

 

 

2018年

 

Highly ordered polypeptide with UCST phase-separation behavior

S Kuroyanagi, N Shimada, S Fujii, T Furuta, A Harada, K Sakurai, K Sakurai,A Maruyama

J. Am. Chem. Soc. 2019, 141, 1261−1268

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Corrigendum to" Designing an immunocyte-targeting delivery system by use of beta-glucan"[Vaccine 36  (2018) 186-189].

N Miyamoto, S Mochizuki, K Kobiyama, KJ Ishii, K Sakurai

Vaccine 36 (45), 6892

 


 

Morphological Transition of Oppositely Charged Calix [4] arene Surfactant Mixture

JH Lee, S Fujii, R Takahashi, K Sakurai

Langmuir 34 (40), 12109-12115

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Core–Shell–Corona Micelles from a Polyether-Based Triblock Terpolymer: Investigation of the pH-ependent Micellar Structure

Shotaro Miwa, Rintaro Takahashi, Carsten Rössel, Sakiko Matsumoto, Shota Fujii, Ji Ha Lee, Felix H. Schacher, Kazuo Sakurai

Langmuir 34 (26), 7813-7820

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Rediscovering the Monodispersity of Sulfonatocalix [4] arene-Based Micelles

S Fujii, JH Lee, R Takahashi, K Sakurai

Langmuir 34 (17), 5072-5078

 



 

A tetramer micelle: the smallest aggregation number corresponding to the vertex number ofregularpolyhedra in platonic micelles

S Fujii, R Takahashi, LJ Ha, K Sakurai

Soft matter 14 (6), 875-878

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Designing an immunocyte-targeting delivery system by use of beta-glucan

N Miyamoto, S Mochizuki, K Sakurai

Vaccine 36 (1), 186-189

 


 

Elongation induced β- to α-crystalline transformation and microvoid
formation in isotactic polypropylene as revealed by time-resolved WAXS/SAXS

Hideo Kurihara,Shinich Kitade,Kazuyuki Ichino,Isamu Akiba,Kazuo Sakurai

Polymer journal 51,199-209

 


 

2017年


 

Cross-sectional structures of a molecular monolayer nanotube explored with SAXS: Evidence for the parallel orientation of the headgroups in asymmetric bolaamphiphiles

Article in Physical Chemistry Chemical Physics 19(36) · August 2017

 


 

A two-component micelle with emergent pH responsiveness by mixing dilauroyl phosphocholine and deoxycholic acid and its delivery of proteins into the cytosol.

Miyamoto N, Fujii S, Mochizuki S, Sakurai K, Sakaguchi N, Koiwai K.

Article inColloids and surfaces B: Biointerfaces 154 · March 2017  

  


 

Self-Assembly of Calix[4]arene-Based Amphiphiles Bearing Polyethylene Glycols: Another Example of “Platonic Micelles”

Kenta Yoshida, Shota Fujii, Rintaro Takahashi , Sakiko Matsumoto, Kazuo Sakurai

Langmuir, 2017, 33 (36), pp 9122–9128    

 


 

Dynamic Viscoelastic Properties of Poly(Ethylene-Propylene) Diblock Copolymer in the Melt State and Solutions

William MacKnightK. Sakurai, D.J. Lohse, D.N. Schulz, J.A. Sissano, W. Wedler, H. H. Winter

ELSEVIER November 1996

DOI: https://works.bepress.com/william_macknight/208/

 


 

Monitoring the Discontinuous Dodecamer–Icosamer Transition of a Calix[4]arene‐Derived Surfactant by Time‐Resolved Small‐Angle X‐ray Scattering

Rintaro Takahashi, Sakiko Matsumoto, Shota Fujii, Theyencheri Narayanan,  Kazuo Sakurai

Ange Wandte 8 May 2017  

        DOI: 10.1002/ange.201702260           

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Glutamic Acids Bearing Calix[4]arene Micelles: pH-Controllable Aggregation Number Corresponding to Regular Polyhedra

        Shota Fujii,Rintaro Takahashi,Kazuo Sakurai

         Langmuir, 2017, 33 (16), pp 4019–4027

         DOI: 10.1021/acs.langmuir.7b00603

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Magnetic metal-complex-conducting copolymer core–shell nanoassemblies for a

single-drug anticancer platform Jeong-Hwan Kim, Haruki Eguchi, Masanari Umemura, Itaru Sato, Shigeki Yamada, Yujiro Hoshino, Takatsugu Masuda, Ichio Aoki, Kazuo Sakurai, Masahiro Yamamoto and Yoshihiro Ishikawa

        PG Asia Materials (2017) 9, e367

        doi:10.1038/am.2017.29

        


 

Ultraviolet Patterned Calixarene-Derived Supramolecular Gels and Films with

Spatially Resolved Mechanical and Fluorescent Properties

Ji Ha Lee , Sung Ho Jung, Shim Sung Lee , Ki-Young Kwon, Kazuo Sakurai, Justyn Jaworski, and Jong Hwa Jung,

ACS Nano, 2017, 11 (4), pp 4155–4164

DOI: 10.1021/acsnano.7b00997


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Platonic Micelles: Mono disperse Micelles with Discrete Aggregation Numbers Corresponding to Regular Polyhedra

Shota Fujii, Shimpei Yamada, Sakiko Matsumoto, Genki Kubo, Kenta Yoshida, Eri Tabata, Rika Miyake, Yusuke Sanada, Isamu Akiba, Tadashi Okobira, Naoto Yagi, Efstratios Mylonas, Noboru Ohta, Hiroshi Sekiguchi, and Kazuo Sakurai.Scientific Reports (2017) 7:44494

DOI:10.1038/srep44494

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Adjuvant activity enhanced by crosslinked CpG-oligonucleotides in beta-glucan nanogel and its anti-tumor effect.

Miyamoto, N.; Mochizuki, S.; Fujii, S.; Yoshida, K.; Sakurai, K., Bioconjugate Chemistry (2016). 28, (2), 565–573,  

DOI:10.1021/acs.bioconjchem.6b00675  .jpg

 


 

Oriented crystallization of long chain branched polypropylene induced by step-shear deformation in pre-crystallization regime.

Kitade, S.; Kurihara, H.; Asuka, K.; Katsuno, S.; Akiba, I.; Sakurai, K., Polymer (2017). Volume 116, 5 May 2017, Pages 395–402

DOI:10.1016/j.polymer.2017.02.005

 


 

Chiral Supramolecular Gels with Lanthanide Ions: Correlation between Luminescence and Helical Pitch.

Kim, C.; Kim, K. Y.; Lee, J. H.; Ahn, J.; Sakurai, K.; Lee, S. S.; Jung, J. H., ACS Applied Materials & Interfaces (2017)9 (4), pp 3799–3807

DOI:10.1021/acsami.6b13916

 


 

Salt-Induced Morphology Transition of Micelles Formed of Calix[4]arene-Derivative Cationic Surfactants in Aqueous Solution.Matsumoto, Sakiko; Takahashi, Rintaro; Yamada, Shimpei; Fujii, Shota ; Sakurai, Kazuo., Chemistry Letters., Accepted.

Concentration-dependent Aggregation Behavior of Asymmetric Cationic Surfactant Hexyldimethyloctylammonium Bromide

author: Anita Hyde, Shota Fujii, Kazuo Sakurai, Chi Phan, and Shin-ichi Yusa (2017),Vol.46, NO.2

DOI: http://dx.doi.org/10.1246/cl.161007

 


 

2016年

Supramolecular Chirality: Vesicle-to-Chiral Helix Transition of the Micelles Consisting of a Sugar-Bearing Calix[4]arene Surfactant.

Sakamoto, S.; Fujii, S.; Yoshida, K.; Sakurai, K., Langumuir 201632 (47), pp 12434–12441

DOI:10.1021/acs.langmuir.6b01671

la-2016-01671e_0010.jpg

 

Water-soluble complex formation of fullerenes with a biocompatible polymer.

Ohata, T.; Ishihara, K.; Iwasaki, Y.; Sangsuwan, A.; Fujii, S.; Sakurai, K.; Ohara, Y.; Yusa, S., Polymer Journal 2016.

DOI:10.1038/pj.2016.60  

 

Micelle formation and red-light fluorescence emission of benzothiazole-triphenylamine amphiphilic molecules in water/methanol solutions explored with synchrotron small-angle X-ray scattering.

Yamada, S.; Sanada, Y; Fujii, S; Kitahara, I.; Akiba, I.; Ishii, T.; Sakurai, K., Polymer Journal 2016.

DOI:10.1038/pj.2016.56


Gene silencing using a conjugate comprising Tat peptide and antisense oligonucleotide with phosphorothioate backbones.

Maegawa, Y.; Mochizuki, S.; Miyamoto, N.; Sakurai, K., Bioorganic & Medicinal Chemistry Letters 2016.

DOI:10.1016/j.bmcl.2016.01.018

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Polypod-Shaped DNAs: Small-Angle X-ray Scattering and Immunostimulatory Activity.

Sanada, Y.; Shiomi, T.; Okobira, T.; Tan, M.; Nishikawa, M.; Akiba, I.; Takakura, Y.; Sakurai, K., Langmuir 2016, 32 (15), 3760-3765.

DOI:10.1021/acs.langmuir.6b00398

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Optimal sequence of antisense DNA to silence YB-1 in lung cancer by use of a novel polysaccharide drug delivery system.

Izumi, H.; Nagao, S.; Mochizuki, S.; Fujiwara, N.; Sakurai, K.; Morimoto, Y., International Journal of Oncology 2016, 48 (6), 2472-2478.

DOI:10.3892/ijo.2016.3451

 

Competition of PEG Coverage Density and Con-A Recognition in Mannose/PEG Bearing Nanoparticles.

Fukuda, I.; Mochizuki, S.; Sakurai, K., Colloids and Surfaces B: Biointerfaces 2016.

DOI:10.1016/j.colsurfb.2016.05.011

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Anomalous small-angle X-ray scattering study on the spatial distribution of hydrophobic molecules in polymer micelles.

Nakanishi, R., Machida, G., Kinoshita, M., Sakurai, K., & Akiba, I., Polymer Journal (2016) 48, 801-806 (July 2016)

DOI:10.1038/pj.2016.32.

 

Exploring the relationship between anti-PEG IgM behaviors and PEGylated nanoparticles and its significance for accelerated blood clearance. Shiraishi, K., Kawano, K., Maitani, Y., Aoshi, T., Ishii, K. J., Sanada, Y., Yokoyama, M. J Control Release(2016), 234, 59-67.

DOI:10.1016/j.jconrel.2016.05.010

   

 

2015年

Amphiphilic benzothiadiazole–triphenylamine-based aggregates that emit red light in water. Ishi-i, T.; Kitahara, I.; Yamada, S.; Sanada, Y.; Sakurai, K.; Tanaka, A.; Hasebe, N.; Yoshihara, T.; Tobita, S., Organic & biomolecular chemistry 2015. 2015,13, 1818-1828. DOI: 10.1039

 

The transfection efficiency of calix [4] arene-based lipids: the role of the alkyl chain length. Mochizuki, S.; Nishina, K.; Fujii, S.; Sakurai, K., Biomater. Sci. 2015, 3 (2), 317-322.

 

Permanent acceptance of mouse cardiac allografts with CD40 siRNA to induce regulatory myeloid cells by use of a novel polysaccharide siRNA delivery system. Zhang, Q.; Ichimaru, N.; Higuchi, S.; Cai, S.; Hou, J.; Fujino, M.; Nonomura, N.; Kobayashi, M.; Ando, H.; Uno, A., Gene therapy 2015.

 

Development of Nonaggregating Poly-A Tailed Immunostimulatory A/D Type CpG Oligodeoxynucleotides Applicable for Clinical Use. Aoshi, T.; Haseda, Y.; Kobiyama, K.; Narita, H.; Sato, H.; Nankai, H.; Mochizuki, S.; Sakurai, K.; Katakai, Y.; Yasutomi, Y., Journal of immunology research 2015.

 

Macrophage-targeting gene delivery using a micelle composed of mannose-modified lipid with triazole ring and dioleoyl trimethylammonium propane. Fukuda, I.; Mochizuki, S.; Sakurai, K., BioMed research international 2015.

 

Rod-like architecture and cross-sectional structure of an amyloid protofilament-like peptide supermolecule in aqueous solution. Minami, T.; Matsumoto, S.; Sanada, Y.; Waku, T.; Tanaka, N.; Sakurai, K., Polymer Journal 2015.

 

Immunization with antigenic peptides complexed with β-glucan induces potent cytotoxic T-lymphocyte activity in combination with CpG-ODNs. Mochizuki, S.; Morishita, H.; Kobiyama, K.; Aoshi, T.; Ishii, K. J.; Sakurai, K., Journal of Controlled Release 2015, 220, 495-502.

 

Synchronized Self-assembly of Fullerene Derivatives Passing Through Programmable Microflow Field. Numata, M.; Kozawa, T.; Nakadozono, T.; Sanada, Y.; Sakurai, K., Chemistry Letters 2015,  (0).

 

Synchronized Activation of π-Conjugated Molecules toward Self-Assembly: Precise Controlling the Hysteresis of the Metastable State along Microflow. Numata, M.; Kozawa, T.; Nogami, R.; Tanaka, K.; Sanada, Y.; Sakurai, K., Bulletin of the Chemical Society of Japan 2015,  (0).

 

Creation of Kinetically Stabilized Porphyrin Microfilms through Synchronized Hydrogen-bonding Interactions in Microflow. Numata, M.; Nishino, Y.; Sanada, Y.; Sakurai, K., Chemistry Letters 2015, 44 (6), 861-863.

 

Determination of polymeric micelles' structural characteristics, and effect of the characteristics on pharmacokinetic behaviors. Shiraishi, K.; Sanada, Y.; Mochizuki, S.; Kawano, K.; Maitani, Y.; Sakurai, K.; Yokoyama, M., Journal of Controlled Release 2015, 203, 77-84.

 

Chain architecture and flexibility of α-cyclodextrin/PEG polyrotaxanes in dilute solutions. Yamada, S.; Sanada, Y.; Tamura, A.; Yui, N.; Sakurai, K., Polymer Journal 2015, 47 (6), 464-467.

 

Prevention of copper-induced cell death by GC-rich DNA oligomers in murine macrophage-like RAW264. 7 cells. Matsushita, S.; Mochizuki, S.; Sakurai, K.; Kawano, T., Communicative & Integrative Biology 2015,  (just-accepted), 00-00.

 

 

2014年

Micelles consisting of choline phosphate-bearing Calix [4] arene lipids. Fujii, S.; Nishina, K.; Yamada, S.;   Mochizuki, S.; Ohta, N.; Takahara, A.; Sakurai, K., Soft matter 2014, 10 (41), 8216-8223.

 

Dectin-1 ligand transforms CpG into a multitask nanoparticulate TLR9 agonist. Kobiyama, K.; Aoshi, T.; Narita, H.; Kuroda, E.; Hayashi, M.; Tetsutani, K.; Koyama, S.; Mochizuki, S.; Sakurai, K.; Katakai, Y., Nonagonistic Proceedings of the National Academy of Sciences 2014, 111 (8), 3086-3091.

 

Transformation from Multi to Single Lamellar Vesicle by Addition of a Cationic Lipid to DLPC Explored with SAXS and TEM.Kubo, G.; Sakamoto, S.; Fujii, S.; Sanada, Y.; Yasunaga, T.; Takahara, A.; Sakurai, K., 2014. Chemistry Letters,Vol. 43 (2014) No. 11 P 1785-1787

 

Naphthalene-hydrophobized β-1, 3-glucan nanogel for doxorubicin delivery to immunocytes Maeda, K.;       Mochizuki, S.; Sanada, Y.; Sakurai, K., Bioorganic & medicinal chemistry letters 2014, 24 (8), 1880-1883.

 

Enhanced Immunostimulation with Crosslinked CpG-DNA/beta-1, 3-Glucan Nanoparticle through Hybridization.;Miyamoto, N.; Mochizuki, S.; Sakurai, K., 2014. Chemistry Letters 43 (7), 991-993

 

Binding assay between murine Dectin-1 and β-glucan/DNA complex with quartz-crystal microbalance. Mochizuki, S.; Morishita, H.; Adachi, Y.; Yamaguchi, Y.; Sakurai, K., Carbohydrate research 2014, 391, 1-8.

 

Chain-length dependence of polyion complex architecture bearing phosphobetaine block explored using SAXS and FFF-MALS. Sakamoto, S.; Sanada, Y.; Sakashita, M.; Nishina, K.; Nakai, K.; Yusa, S.-i.; Sakurai, K.,. Polymer Journal 2014. 46, 617-622; doi:10.1038

 

Hepatocyte-targeting gene delivery using a lipoplex composed of galactose-modified aromatic lipid synthesized with click chemistry. Sakashita, M.; Mochizuki, S.; Sakurai, K., Bioorganic & medicinal chemistry 2014, 22 (19), 5212-5219.

 

X-ray Scattering from Immunostimulatory Tetrapod-Shaped DNA in Aqueous Solution To Explore Its Biological Activity–Conformation Relationship. Sanada, Y.; Sakamoto, S.; Shiomi, T.; Okobira, T.; Mylonas, E.; Ohta, N.; Yagi, N.; Nishikawa, M.; Akiba, I.; Takakura, Y., The Journal of Physical Chemistry B 2014, 118 (35), 10373-10379.

 

Advanced Soft Material Beamline Consortium at SPring-8 (FSBL). Takahara, A.; Takeda, T.; Kanaya, T.; Kido, N.; Sakurai, K.; Masunaga, H.; Ogawa, H.; Takata, M., Synchrotron Radiation News 2014, 27 (3), 19-23.

 

The dectin 1 agonist curdlan regulates osteoclastogenesis by inhibiting nuclear factor of activated T cells cytoplasmic 1 (NFATc1) through Syk kinase. Yamasaki, T.; Ariyoshi, W.; Okinaga, T.; Adachi, Y.; Hosokawa, R.; Mochizuki, S.; Sakurai, K.; Nishihara, T., Journal of Biological Chemistry 2014, 289 (27), 19191-19203.

2013年

The role of the helper lipid dioleoylphosphatidylethanolamine (DOPE) for DNA transfection cooperating with a cationic lipid bearing ethylenediamine.  Mochizuki S, Kanegae N, Nishina K, Kamikawa Y, Koiwai K, Masunaga H, Sakurai K.  Biochim. Biophys. Acta.1828(2), 412-418 (2013). 10.1016/j.bbamem.2012.10.017

 

A simple visual sensor with the potential for determining the concentration of fluoride in water at environmentally significant levels. Tomoki Nishimura ,  Su-Ying Xu ,  Yun-Bao Jiang ,  John S. Fossey ,  Kazuo Sakurai ,  Steven D. Bull and Tony D. James. Chemical Communications, 2013,49, 478-480 DOI: 10.1039/C2CC36107H

 

Hydrophobic Molecules Infiltrating into the Poly(ethylene glycol) Domain of the Core/Shell Interface of a Polymeric Micelle: Evidence Obtained with Anomalous Small-Angle X-ray Scattering. Yusuke Sanada, Isamu Akiba, Kazuo Sakurai, Kouichi Shiraishi, Masayuki Yokoyama, Efstratios Mylonas, Noboru Ohta, Naoto Yagi, Yuya Shinohara , and Yoshiyuki Amemiya. Journal of the American Chemical Society. Publication Date (Web): January 31, 2013 DOI 10.1021/ja308965j

 

A bimolecular micelle constructed from amphiphilic pillar[5]arene molecules. Tomoki Nishimura , Yusuke Sanada , Takuma Matsuo ,  Tadashi Okobira , Efstratios Mylonas , Naoto Yagi and Kazuo Sakurai. Chem. Commun., 2013, 49, 3052-3054 DOI: 10.1039/C3CC41186A

 

Structural Transition of Lipopolysaccharide and Reduction in the Biological Activity by Amphiphilic Lipid with Cationic Amino Acid.  Li, Wenjing; Mochizuki, Shinichi; Sakurai, Kazuo. Bull. Chem. Soc. Jpn. in press

 

糖アルコールを有するカチオン性ミセルのpH応答性による構造転移. 松尾拓馬、藤井翔太、眞田雄介、櫻井和朗. 高分子論文集 in press

 

Macrophage specific delivery of TNF- siRNA complexed with -1,3-glucan inhibits LPS-induced cytokine production in a murine acute hepatitis model Bioorganic & Medicinal Chemistry. In press

Structural Transition of Lipopolysaccharide and Reduction in the Biological Activity by Amphiphilic Lipid with Cationic Amino Acid.  Li, Wenjing; Mochizuki, Shinichi; Sakurai, Kazuo. Bull. Chem. Soc. Jpn. Vol. 862013No.5, P651-656. Doi.org/10.1246/bcsj.20120353 

 

Structural Analysis of a Polymeric Micelle Made from AB3-type Multiarmed Star-like Block Copolymer in an Aqueous Solution. Sanada, Yusuke; Sakamoto, Shunsuke; Akiba, Isamu; Takaki, Toshihiko; Sakurai, Kazuo. Chemistry Letters. Vol.42 No.8 2013 p.882–884 August 5, 2013 doi:10.1246/cl.130285

 

Synthesis and Characterization of a Calix[4]arene Amphiphilie Bearing Cysteine and Uniform Au Nanoparticle Formation Templated by its Four Cysteine Moieties. Fujii, Shota; Sakurai, Kazuo; Okobira, Tadashi; Ohta, Noboru; Takahara, Atsushi. Langmuir. Vol.29 No.45 p.13666-13675 (2013). doi: 10.1021/la403377a.

 

Preparation and Characterization of Polyion Complex Micelles with Phosphobetaine Shells. Nakai K, Nishiuchi M, Inoue M, Ishihara K, Sanada Y, Sakurai K, Yusa S. Langmuir. Vol.29 No.31 p.9651-9661 (2013). doi: 10.1021/la401063b

 

Menthol-enhanced Cytotoxicity of Cigarette Smoke Demonstrated in Two Bioassay Models. Noriyasu A, Konishi T, Mochizuki S, Sakurai K, Tanaike Y, Matsuyama K, Uezu T, Kawano T. Tob. Induc. Dis. Vol. 11 No.1 p.18-22 (2013). doi: 10.1186/1617-9625-11-18.

 

Crystallization kinetics of polypropylene containing a sorbitol nucleating agent. Katsuno, Satoshi; Yoshinaga, Masahiro; Kitade, Shinichi; Sanada, Yusuke; Akiba, Isamu; Sakurai, Kazuo, Masunaga, Hiroyasu; Polym J., Vol. 45 No.1 p. 87-93(2013). doi: 10.1038/pj.2012.199

 

Shear-induced pre-crystallization structures of long chain branched polypropylene under steady shear flow near the melting temperature, Kitade, Shinichi; Asuka, Kazuo; Akiba, Isamu; Sanada, Yusuke; Sakurai, Kazuo; Masunaga, Hiroyasu, Polymer, Vol. 54 No.1 p. 246-257 (2013). Doi: 10.1016/j.polymer.2012.10.048

 

Accurate measurements of intrinsic scattering from window materials by use of a vacuum camera, H. Masunaga, K. Sakurai, I. Akiba, K. Ito and M. Takata, J. Appl. Cryst., Vol. 46 p. 577-579 (2013).   doi:10.1107/S0021889813002628

 

Study of the internal structure of polymer micelles by anomalous small-angle X-ray scattering at two edges, M. Sakou, A. Takechi, S. Murakami, K. Sakurai and I. Akiba, J. Appl. Cryst., Vol. 46, p. 1407-1413 (2013). doi:10.1107/S0021889813022450

 

Pyrene-anchored boronic acid receptors on carbon nanoparticle supports: fluxionality and pore effects, Katherine Lawrence, Tomoki Nishimura, Peter Haffenden, John M. Mitchels, Kazuo Sakurai, John S. Fossey, Steven D. Bull, Tony D. Jamesa and Frank Marken, New J. Chem., Vol. 37 p. 1883-1888 (2013). doi: 10.1039/C3NJ00017F

 

1.                    Structural Transition of Lipopolysaccharide and Reduction in the Biological Activity by Amphiphilic Lipid with Cationic Amino Acid.  Li, Wenjing; Mochizuki, Shinichi; Sakurai, Kazuo. Bull. Chem. Soc. Jpn. Vol. 862013No.5, P651-656. Doi.org/10.1246/bcsj.20120353

 

2.        Structural Analysis of a Polymeric Micelle Made from AB3-type Multiarmed Star-like Block Copolymer in an Aqueous Solution. Sanada, Yusuke; Sakamoto, Shunsuke; Akiba, Isamu; Takaki, Toshihiko; Sakurai, Kazuo. Chemistry Letters. Vol.42 No.8 2013 p.882–884 August 5, 2013 doi:10.1246/cl.130285

 

3.         Synthesis and Characterization of a Calix[4]arene Amphiphilie Bearing Cysteine and Uniform Au Nanoparticle Formation Templated by its Four Cysteine Moieties. Fujii, Shota; Sakurai, Kazuo; Okobira, Tadashi; Ohta, Noboru; Takahara, Atsushi. Langmuir. Vol.29 No.45 p.13666-13675 (2013). doi: 10.1021/la403377a.

 

4.         Preparation and Characterization of Polyion Complex Micelles with Phosphobetaine Shells. Nakai K, Nishiuchi M, Inoue M, Ishihara K, Sanada Y, Sakurai K, Yusa S. Langmuir. Vol.29 No.31 p.9651-9661 (2013). doi: 10.1021/la401063b

 

5.         Menthol-enhanced Cytotoxicity of Cigarette Smoke Demonstrated in Two Bioassay Models. Noriyasu A, Konishi T, Mochizuki S, Sakurai K, Tanaike Y, Matsuyama K, Uezu T, Kawano T. Tob. Induc. Dis. Vol. 11 No.1 p.18-22 (2013). doi: 10.1186/1617-9625-11-18.

 

6.         Crystallization kinetics of polypropylene containing a sorbitol nucleating agent. Katsuno, Satoshi; Yoshinaga, Masahiro; Kitade, Shinichi; Sanada, Yusuke; Akiba, Isamu; Sakurai, Kazuo, Masunaga, Hiroyasu; Polym J., Vol. 45 No.1 p. 87-93(2013). doi: 10.1038/pj.2012.199

 

7.         Shear-induced pre-crystallization structures of long chain branched polypropylene under steady shear flow near the melting temperature, Kitade, Shinichi; Asuka, Kazuo; Akiba, Isamu; Sanada, Yusuke; Sakurai, Kazuo; Masunaga, Hiroyasu, Polymer, Vol. 54 No.1 p. 246-257 (2013). Doi: 10.1016/j.polymer.2012.10.048

 

8.         Accurate measurements of intrinsic scattering from window materials by use of a vacuum camera, H. Masunaga, K. Sakurai, I. Akiba, K. Ito and M. Takata, J. Appl. Cryst., Vol. 46 p. 577-579 (2013).   doi:10.1107/S0021889813002628

 

9.         Study of the internal structure of polymer micelles by anomalous small-angle X-ray scattering at two edges, M. Sakou, A. Takechi, S. Murakami, K. Sakurai and I. Akiba, J. Appl. Cryst., Vol. 46, p. 1407-1413 (2013). doi:10.1107/S0021889813022450

 

10.      Pyrene-anchored boronic acid receptors on carbon nanoparticle supports: fluxionality and pore effects, Katherine Lawrence, Tomoki Nishimura, Peter Haffenden, John M. Mitchels, Kazuo Sakurai, John S. Fossey, Steven D. Bull, Tony D. Jamesa and Frank Marken, New J. Chem., Vol. 37 p. 1883-1888 (2013). doi: 10.1039/C3NJ00017F

 

11.      Dual-Sugar Nanogel Comprising β-1,3-Glucan and Cholesterol-Bearing Dextran for Protein-Delivery Targeting Antigen Presenting Cells Authors Maegawa, Yoshiya; Mochizuki, Shinichi; Sanada, Yusuke; Akiyoshi, Kazunari; Sakurai, Kazuo. Chemistry Letters. in press

 

12.      A non-agonistic Dectin-1 ligand transforms CpG into a multitask nano-particulate TLR9 agonist. Kobiyama K, Aoshi T, Narita H, Kuroda E, Hayashi M, Tetsutani K, Koyama S, Mochizuki S, Sakurai K, Katakai Y, Yasutomi Y, Saijo S, Iwakura Y, Akira S, Coban C, Ishii K. Proc. Natl. Acad. Sci. U.S.A. in press. 

 

2012年

 A Stimulus-Responsive Shape-Persistent Micelle Bearing a Calix[4]arene Building Block: Reversible pH-Dependent Transition between Spherical and Cylindrical Forms. Shota Fujii, Yusuke Sanada, Tomoki Nishimura, Isamu Akiba, and Kazuo Sakurai , Naoto Yagi and Efstratios Mylonas. Langmuir, 2012, 28 (6), pp 3092–3101, DOI: 10.1021/la2037668

 

 

 

β-1,3-d-Glucan Schizophyllan/Poly(dA) Triple-Helical Complex in Dilute Solution. Yusuke Sanada, Tsubasa Matsuzaki, Shinichi Mochizuki, Tadashi Okobira, Kazuya Uezu, and Kazuo Sakurai. J. Phys. Chem. B, 2012, 116 (1), pp 87–94, DOI: 10.1021/jp209027u

 

 

 

A New Therapeutic Approach Using a Schizophyllan-based Drug Delivery System for Inflammatory Bowel Disease. Hidetoshi Takedatsu, Keiichi Mitsuyama, Shinichi Mochizuki, Teppei Kobayashi, Kazuo Sakurai, Hiroshi Takeda, Yoshihide Fujiyama, Yoshikazu Koyama, Jun Nishihira and Michio Sata. Molecular Therapy , 20, 1234-1241 (June 2012) doi:10.1038/mt.2012.24

 

 

Rapid separation of proteins from the aqueous media using the novel gelation protocol. Takashi Kadono, Yasuaki Fukuta, Kazuya Uezu, Hiroshi Morita, Kazuo Sakurai, and Tomonori Kawano. Current Topics in Peptide & Protein Research.

 

 

Modeling and Evaluation of a Twist Drive Actuator for Soft Robotics. Ivan Godler , Takashi Sonoda and Kazuo Sakurai. Advanced Robotics 26 (2012) 765–783. DOI:10.1163/156855312X626307

 

 

Relationship between DNA-Transfection Efficiency and Chemical Structures of Aromatic Cationic Lipids. Shinichi Mochizuki, Yumi Kamikawa, Koichi Nishina, Shota Fujii, Emi Hamada, Shota Kusuki, Takuma Matsuo, and Kazuo Sakurai. Bull. Chem. Soc. Jpn. Vol. 85, No. 3, 354-359(2012), DOI: 10.1246/bcsj.20110296

 

 

Thermodynamics of Lipoplex Formation: Relationship between the Lipid Alkyl Tail Length and Thermodynamic Functions. Shota Fujii, Tomoki Nishimura, and Kazuo Sakurai. Chem. Lett. Vol.41, No.5, pp.501--503, (2012)

 

 

 

Anomalous Small-Angle X-ray Scattering Study of Structure of Polymer Micelles Having Bromines in Hydrophobic Core. Isamu Akiba, Atsuro Takechi, Megumi Sakou, Masashi Handa, Yuya Shinohara, Yoshiyuki Amemiya, Naoto Yagi, and Kazuo Sakurai. Macromolecules, (Web): July 23, 2012 (Article) DOI: 10.1021/ma300461d.

 

 

 

Composition Dependence of the Micellar Architecture Made from Poly(ethylene glycol)-block-Poly(partially benzyl-esterified aspartic acid). Yusuke Sanada, Isamu Akiba, Satoshi Hashida, and Kazuo Sakurai , Kouichi Shiraishi and Masayuki Yokoyama , Naoto Yagi , Yuya Shinohara and Yoshiyuki Amemiya. J. Phys. Chem. B, (2012), 116 (28), pp 8241–8250. DOI: 10.1021/jp300936d

 

 

多糖β-1,3-グルカンの受容体を利用したオリゴ核酸の選択的デリバリー 宮本 寛子, 望月慎一, 櫻井 和朗Cellulose communications 19(1), 12-16, 2012

 

 

SAXSとFFF-MALSを組合せた高分子ミセルのキャラクタリゼーション. 真田 雄介, 秋葉 勇, 橋田智史, 白石 貢一, 横山 昌幸, 八木 直人, 篠原 裕也, 雨宮慶幸, 櫻井 和朗. 高分子論文集 Vol. 69 (2012) No. 7 p. 346-357

 

 

カチオン性脂質ミセルと DNA が形成する複合体の超分子構造 —構造のDNA 鎖長と塩基種依存性—. 飯野智絵, 櫻木美菜, 増永啓康, 櫻井和朗.  高分子論文集 Vol. 69 (2012) No. 2 , P 84-88

 

 

Dependence of the swelling of a pH-responsive PEG-modified nanogel on the cross-link density. G. Tamura, Y. Shinohara, A. Tamura, Y. Sanada, M. Oishi, I. Akiba, Y. Nagasaki, K. Sakurai, and Y. Amemiya, Polymer Journal, 44, 240-244 (2012)

 

 

The role of the helper lipid dioleoylphosphatidylethanolamine (DOPE) for DNA transfection cooperating with a cationic lipid bearing ethylenediamine. Mochizuki, S.; Kanegae, N.; Nishina, K.; Kamikawa, Y.; Koiwai, K.; Masunaga, H.; Sakurai, K. Biochimica et Biophysica Acta (BBA) – Biomembranes (2012) web

 

 

Shear-induced pre-crystallization structures of long chain branched polypropylene under steady shear flow near the melting temperature.

Kitade, S.; Asuka, K.; Akiba, I.; Sanada, Y.; Sakurai, K.; Masunaga, H. Polymer (2012) web

 

 

ssDNA–dsRNAs are cleaved at the next to its chimera-junction point by an unknown RNase activity. Mochizuki, S.; Higuchi, S.; Sakurai, K. Biochemical and Biophysical Research Communications (2012) web

 

 

Crystallization kinetics of polypropylene containing a sorbitol nucleating agent. Satoshi Katsuno, Masahiro Yoshinaga, Shinichi Kitade, Yusuke Sanada, Isamu Akiba, Kazuo Sakurai and Hiroyasu Masunaga. Polymer Journal , (14 November 2012)  doi:10.1038/pj.2012.199 web

 

 

Exploiting the Reversible Covalent Bonding of Boronic Acids: Recognition, Sensing, and Assembly. Steven D Bull, Matthew G. Davidson, Jean M. H. van den Elsen, John S. Fossey , A. Toby A. Jenkins, Yun-Bao Jiang , Yuji Kubo , Frank Marken, Kazuo Sakurai, Jianzhang Zhao , and Tony D. James. Accounts of chemical research. Publication Date (Web): November 14, 2012  DOI: 10.1021/ar300130w

 

 

A simple visual sensor with the potential for determining the concentration of fluoride in water at environmentally significant levels. Tomoki Nishimura, Su-Ying Xu, Yun-Bao Jiang, Kazuo Sakurai, Steven D. Bull, and Tony D. James. ChemComm. Nov 12, 2012 accepted

2012年(著作)

2011年

Transformation from Multilamellar to Unilamellar Vesicles by Addition of a Cationic Lipid to PEGylated Liposomes Explored with Synchrotron Small Angle X-ray Scattering. Sakuragi, M.; Koiwai, K.; Nakamura, K.; Masunaga, H.; Ogawa, H.; Sakurai, K. In, Journal of Physics. 272(2011),  doi:10.1088/1742-6596/272/1/012011

 

 

 

Dectin-1 targeting delivery of TNF-a antisense ODNs complexed with b-1,3-glucan protects mice from LPS-induced hepatitis. Shinichi Mochizuki, and Kazuo Sakurai. Journal of Controlled Release. Volume 151, Issue 2, 30 April 2011, 155-161

 

 

 

Enhanced Cytokine Secretion from Primary Macrophages due to Dectin-1 Mediated Uptake of CpG DNA/β-1,3-glucan Complex. Minari, Jusaku; Mochizuki, Shinichi; Matsuzaki, Tsubasa; Adachi, Yoshiyuki; Ohno, Naohito; Sakurai, Kazuo. Bioconjugate Chemistry  22 p9-15, DOI: 10.1021/bc1001196

 

 

Thermosensitive Molecular Assemblies from Poly(amidoamine)Dendron-Based Lipids. Kenji Kono, Etsuo Murakami, Yuki Hiranaka, Eiji Yuba, Chie Kojima, Atsushi Harada, and Kazuo Sakurai. A journal of the Gesellschaft Deutscher Chemiker Angewandte Chemie 2011 50/28 p6332-6336  DOI:10.1002/anie.201101007

 

 

 

Multipurpose soft-material SAXS/WAXS/GISAXS beamline at SPring-8. Hiroyasu Masunaga, Hiroki Ogawa, Takumi Takano, Sono Sasaki, Shunji Goto, Takashi Tanaka, Takamitsu Seike, Sunao Takahashi, Kunikazu Takeshita, Nobuteru Nariyama, Haruhiko Ohashi, Toru Ohata, Yukito Furukawa, Tomohiro Matsushita, Yasuhide Ishizawa, Naoto Yagi, Masaki Takata, Hideo Kitamura, Kazuo Sakurai, Kohji Tashiro, Atsushi Takahara, Yoshiyuki Amamiya, Kazuyuki Horie, Mikihito Takenaka, Toshiji Kanaya, Hiroshi Jinnai, Hiroshi Okuda, Isamu Akiba, Isao Takahashi, Katsuhiro Yamamoto, Masamichi Hikosaka, Shinichi Sakurai, Yuya Shinohara, Akihiko Okada and Yasunori Sugihara. Polymer Journal.(2011)43, 471-477

 

 

Quaternary-ammonium-bearing Aromatic Surfactants: Effect of the Alkyl Chain Positions on Their Micelle and DNA-complex Structures. Takuma Matsuo, Shota Fujii, Yumi Kamikawa, Tomoki Nishimura, Yusuke Sanada, Shinichi Mochizuki and Kazuo Sakurai. Chemistry Letters . Vol. 40 (2011) , No. 12 p.1340-1342. doi:10.1246/cl.2011.1340 

 

 

Metal-ion induced transition from multi-to single-bilayer tubes in histidine bearing lipids and formation of monodisperse Au nanoparticles. Tomoki Nishimura, Takuma Matsuo and Kazuo Sakurai. Physical Chemistry Chemical Physics. 2011, 13, 15899-15905  DOI: 10.1039/C1CP21065C

 

 

Increased Cellular Transfection with Magnetized DNA/Benzyl Amine Lipid Complexes. Mina Sakuragi, Shinichi Mochizuki and Kazuo Sakurai. Bulletin of the Chemical Society Japan. Vol.84, No.8, 2011 P839-844, August 15.

2010年

Immunogenicity of Whole-Parasite Vaccines against Plasmodium falciparum Involves Malarial Hemozoin and Host TLR9. Cevayir Coban, Yoshikatsu Igari, Masanori Yagi, Thornik Reimer, Shohei Koyama, Taiki Aoshi, Keiichi Ohata, Toshihiro Tsukui, Fumihiko Takeshita, Kazuo Sakurai, Takahisa Ikegami, Atsushi Nakagawa, Toshihiro Horii, Gabriel Nunez, Ken J. Ishii, and Shizuo Akira1. Cell Host & Microbe. Volume7, Issue 1, 50-61, (2010)

 

 

 

Encapsulation of a Hydrophobic Drug into a Polymer-Micelle Core Explored with Synchrotron SAXS. Akiba, I.; Terada, N.; Hashida, S.; Sakurai, K.; Sato, T.; Shiraishi, K.; Yokoyama, M.; Masunaga, H.; Ogawa, H.; Ito, K.; Yagi, N. Langmuir, 26, 7544-7551(2010)  DOI: 10.1021/la904355p

 

 

Cation-specific Transition from Vesicle to Lamella for an Aromatic Diamine Lipid in Aqueous Solutions. Tomoki Nishimura, Hiroyasu Masunaga, Hiroki Ogawa, Isamu Akiba and Kazuo Sakurai. Chemistry Letters. Vol. 39  , No. 7 p.686 (2010)  doi:10.1246/cl.2010.686

 

 

Plasmacytoid Dendritic Cells Delineate Immunogenicity of Influenza Vaccine Subtypes. Shohei Koyama, Taiki Aoshi, Takeshi Tanimoto, Yutaro Kumagai, Kouji Kobiyama, Takahiro Tougan, Kazuo Sakurai, Cevayir Coban1, Toshihiro Horii, Shizuo Akira, and Ken J. Ishii. Science, Transl. Med 3 25 (2010)

 

 

Flexibility and Local Structure of the Wormlike Cylinder in the Organogel of Self-Assembled Discotic Triazine Triamide. Yasuya Kudo ,Mina Sakuragi , Satoshi Hashida , Tsutomu Ishii , Hiroyasu Masunaga, Kazuo Sakurai. Polymer Journal. doi:10.1038/pj.2010.72

 

 

Synthesis of a Highly Hydrophobic Cationic Lipid and its Structural and Thermodynamic Studies for Interaction with DNA. Tomoki Nishimura, Takeshi Cho, Andrew M. Kelley, Magdalena E. Powell, John S. Fossey, Steven D. Bull, Tony D. James, Hiroyasu Masunaga, Isamu Akiba, Kazuo Sakurai. Vol. 83 (9), 1010-1018, Bulletin of the Chemical Society of Japan.  doi:10.1246/bcsj.20100072

 

 

b-1,3-glucan/Antisense Oligonucleotide Complex Stabilized with Phosphorothioation and its Gene Suppression. Shinichi Mochizuki and Kazuo Sakurai. Bioorganic Chemistry Vol. 38. P260-264 (2010)  doi:10.1016/j.bioorg.2010.07.001

 

 

Self-Assembled Synthetic Viral Capsids from a 24-mer Viral Peptide Fragment. Matsuura, Kazunori; Watanabe, Kenta; Matsuzaki, Tsubasa; Sakurai, Kazuo; Kimizuka, Nobuo. Angewandte Chem. 49. P9662-9665, (2010). DOI: 10.1002/ange.201004606

 

 

Self-Assembly of Amphiphilic Block Copolymers Containing Poly(n-octadecyl acrylate) Block in Aqueous Solution. Isamu Akiba, Yusuke Akino, Hiroyasu Masunaga and Kazuo Sakurai. Mater. Sci. Eng. 14 012009 (2010).  doi: 10.1088/1757-899X/14/1/012009

2009年

Flexibility and Cross-Sectional Structure of an Anionic Dual-Surfactant Wormlike Micelle Explored with Small-Angle X-Ray Scattering Coupled with Contrast Variation Technique. Kenzo Naruse, Kenichi Eguchi, Isamu Akiba, Kazuo Sakurai, Hiroyasu Masunaga, Hiroki Ogawa, and John S. Fossey. The Journal of Physical Chemistry B, 113 (30), 10222–10229 (2009)

 

 

Supramolecular Structures of Benzyl Amine Derivate/DNA Complexes Explored with Synchrotron Small Angle X-ray Scattering at SPring-8. Mina Sakuragi, Shouta Kusuki, Emi Hamada, Hiroyasu Masunaga, Hiroki Ogawa, Isamu Akiba, and Kazuo Sakurai. Journal of Physics (Conference Series for IUMRS-ICA 2008), 184, 012008 (2009)

 

 

 

A Novel Polysaccharide/Polynucleotide Complex and its Application to Bio-functional DNA Delivery System. Shinichi Mochizuki and Kazuo Sakurai. Polymer Journal, vol.41, 343-353 No.5 (2009) (Award account)

 

 

Octadecylsilyl silica column method for extraction of messenger RNA. Taro Kimura, Kazuo Sakurai, and Seiji Shinkai. Analytical Biochemistry, 391, 72-73 (2009)

 

 

Antisense Oligonucleotides Delivery to the Antigen Presenting Cells by using Schizophyllan. Shinichi Mochizuki, Jusaku Minari and Kazuo Sakurai. MRS Fall Meeting Symposium HH (in press).

 

 

「ポリカチオンに誘起された5'-GMP希薄溶液からのG-ワイアーの形成」上原周一朗、櫻木美菜、櫻井和朗 高分子論文集 66, 179 (2009)

 

 

「カチオン性ミセルとDNAが形成する超分子構造と遺伝子導入効率の関係」櫻木 美菜、楠木 翔太、濱田 衣美増永 啓康、佐々木 園、櫻井 和朗 高分子論文集 66, 211 (2009)

 

 

Synthesis of calcium phosphate-binding liposome for drug delivery. Takahisa Anada, Yoichi Takeda, Yoshitomo Honda, Kazuo Sakurai, and Osamu Suzuki. Bioorganic & Medicinal Chemistry Letters, 19 (15), 4148-4150 (2009).

2008年

Polysaccharide-Templated Twisted Assemble of 2-Anilinonaphthalene-6-Sulfonic Acid. Naohiko Shimada, Tadashi Okobira, Yoichi Takeda, Seiji Shinkai, Kazuo Sakurai. J. Polymer Science Part A;46,1440-1448 (2008).

 

 

Clustered CpG Sequences to Enhance Cytokine Secretion from Macrophages.  Jusaku Minari, Naohiko Shimada, and Kazuo Sakurai Chemistry Letters;37(1),92-93 (2008).

 

 

Intramolecular Cation–π Interactions Control the Conformation of Nonrestricted (Phenylalkyl)Pyridinesw. Isabella Richter, Jusaku Minari, Philip Axe, John P. Lowe, Tony D. James, Kazuo Sakurai, Steven D. Bull and John S. Fossey. ChemComm. 1082 – 1084 (2008).

 

 

 

Molecular Dynamics Studies of Side Chain Effect on the β-1,3-D-Glucan Triple Helix in Aqueous Solution. Okobira, T.; Miyoshi, K.; Uezu, K.; Sakurai, K.; Shinkai, S. Biomacromolecules; 9(3); 783-788 (2008).

 

 

Entrapment of Immature Amyloid Protofilaments in the Hydrophobic Domain of Schizophyllan. Sakuragi, M.; Takeda, Y.; Shimada, N.; Sakurai, K.; Polymer Bulletin; 1(61); 107-117 (2008).

 

 

3’ Poly(dA)-Tailed Thrombin DNA Aptamer to Increase DNase-Resistance and Clotting Inhibitory Activity. Shuichiro Uehara1, Naohiko Shimada, Yoichi Takeda, Yoshikazu Koyama,Yoshifumi Takei, Hironori Ando, Susumu Satoh, Atsushi Uno, and Kazuo Sakurai; Bull. Chem. Soc. Jpn.;81(11) ;1485-1491 (2008),

 

 

Enhanced Cytokine Secretion Owing to Multiple CpG Side Chains of DNA Duplex. Jusaku Minari, Shinich Motizuki, and Kazuo Sakura. Oligonucleotides.; 18(4); 337-344 (2008)

 

 

Amidine-Bearing lipoplex targeting to hepatocyte cells. Yasuya Kudoa, Kazunori Koiwaib, Kazuhiro Shimizub, Shota Kusukia, Mina Sakuragia, Naohiko Shimadaa, Yoichi Takedaa and Kazuo Sakurai Chinese Chemical Letters. Volume 19, Issue 9, September 2008, Pages 1115-1118

 

 

Solid State Structures and Solution Analyses of a Phenylpropylpyridine N-Oxide and an N-Methyl Phenylpropylpyridine Isabella Richter, Mark R. Warren, Jusaku Minari, Souad A. Elfeky, Wenbo Chen, Mary F. Mahon, Paul R. Raithby, Tony D. James, Kazuo Sakurai, Simon J. Teat, Steven D. Bull and John S. Fossey Chemistry Asian Journal ;4,194-198(2008)

2007年

Complex Made from Tetrasodium N,N-Bis(carboxymethyl) Glutamate Salt and Sodium Oleate that Forms a Highly Ordered Lamella in Gel Phase. Jeong, Y., Uezu. K., Sakurai, S., Masunaga, H., Inoue, K., Sasaki, S., Shimada, N., Takeda, Y., Kaneko, K. and Sakurai, K. Bull. Chem. Soc. Jpn.; 80(2), 410-417 (2007).

 

 

Ternary Complex Consisting of DNA, Polycation, and a Natural Polysaccharide of Schizophyllan to Induce Cellular Uptake by Antigen Presenting Cells. Yoichi Takeda, Naohiko Shimada, Kenji Kaneko, Seiji Shinkai, and Kazuo Sakurai. Biomacromolecules; 2(3), 1178-1186 (2007).

 

 

DNA Conformational Switching by Use of an Intercalator and Its Receptor. Tomoki Nishimura, Yoichi Takeda, Naohiko Shimada, and Kazuo Sakurai1. Chemistry Letters; 36( 3 )388-389 (2007).

 

 

Instantaneous Inclusion of a Polynucleotide and Hydrophobic Guest Molecules into a Helical Core of Cationic -1,3-Glucan Polysaccharide. Ikeda, M.; Hasegawa, T.; Numata, M.; Sugikawa, K.; Sakurai, K.; Fujiki, M.; Shinkai, S.  J. Am. Chem. Soc.; 129(13), 3979-3988 (2007)

 

 

Salt-Concentration Dependence of the Structure and Form Factors for the Wormlike-Micelle Made from LES/AMPB Dual-Surfactant in Aqueous Solution. Kenichi Eguchi, Isamu Kaneda, Yoshiko Hiwatari, Hiroyasu Masunagac and Kazuo Sakurai. J. Applied Crystallography; 40, 264–268 (2007).

 

 

 

A Polysaccharide Carrier to Effectively Deliver Native Phosphodiester CpG DNA to Antigen-Presenting-Cells. Naohiko Shimada, Cevayir Coban, Yoichi Takeda, Masami Mizu, Jusaku Minari, Takahisa Anada, ,Yuichi Torii, Seiji Shinkai, Shizuo Akira, Ken J. Ishii, Kazuo Sakurai. Bioconjugate Chem. 1136-1140 (2007)

 

 

Delivery of Antisense Oligonucleotides to Nuclear Telomere RNA by Use of a Complex between Polysaccharide and Polynucleotide. Jusaku Minari, Takanori Kubo, Hideki Ohba, Naohiko Shimada, Yoich Takeda, Ryouji Karinaga, Takahisa Anada, Kazuya Koumoto, Takeshi Kawazu, Takeshi Nagasaki, Seiji Shinkai, and Kazuo Sakurai. Bull. Chem. Soc. Jpn.; 80(6), 1091-1098 (2007).

 

 

DNA Binding of Tilorone; 1H NMR and Calorimetric Studies of the Intercalation. Tomoki Nishimura, Tadashio Okobira, Andrew M. Kelly, Naohiko Shimada, Yoichi Takeda, and Kazuo Sakurai. Biochemistry;46(27), 8156 -8163 ,(2007).

 

 

Complex Formathion between Cationic β-1,3-Giukan and Hetero-Sequence Oligodeoxynucleotide and        Its Delivery into Macrophage-Like Cell to Induce Cytokine Secretion. M.Ikeda, J.Minari, N.Shimada, M.Numata, K.Sakurai, and S.shinkai.Org.Biomol.chem;5,2219-2224,(2007)

2006年

An enantiomeric nanoscale architecture obtained from a pseudoenantiomeric aggregate: Covalent fixation of helical chirality formed in Self-Assembled discotic triazine triamides by chiral amplification. Ishi-I, Tsutomu; Kuwahara, Rempei; Takata, Akihiko; Jeong, Yeonhwan; Sakurai, Kazuo; Mataka, Shuntaro.  Chemistry European Journal (2006), 12(3), 763-776.

 

 

Click Chemistry on Curdlan: A Regioselective and Quantitative Approach to Develop Artificial β-1,3-Glucans with Various Functional Appendages. Hasegawa, Teruaki; Umeda, Mariko; Numata, Munenori; Fujisawa, Tomohisa; Haraguchi, Shuichi; Sakurai, Kazuo; Shinkai, Seiji. Chemistry Letters  (2006), 35(1), 82-83.

 

 

Galactose-PEG dual Conjugation of B-(1→3)-D-Glucan Schizophyllan for Antisense Oligonucleotides Delivery to Enhance The Cellular Uptake. Karinaga, Ryouji; Anada, Takahisa; Minari, Jusaku; Mizu, Masami; Koumoto, Kazuya; Fukuda, Junji; Nakazawa, Kohji; Hasegawa, Teruaki; Numata, Munenori; Shinkai, Seiji; Sakurai, Kazuo. Biomaterials 27(8), 1626-1635, (2006).

 

 

CpG DNA/Zymosan Complex to Enhance Cytokine Secretion Owing to The Cocktail Effect. Anada, Takahisa; Okada, Naoko; Minari, Jusaku; Karinaga, Ryouji; Mizu, Masami; Koumoto, Kazuya; Shinkai, Seiji; Sakurai, Kazuo. Bioorganic & Medicinal Chemistry Letters 16(5), 1301-1304, (2006).

 

 

計算化学を用いた多糖/核酸複合体の構造検討 三好賢太郎、上江洲一也、櫻井和朗、新海征治 高分子論文集 63(.7)、451-457(2006)

 

 

多糖・核酸複合体を利用したアンチセンスDNAの肝細胞への効果的なデリバリー 狩長亮二、三成寿作、櫻井和朗、新海征治 高分子論文集 63(.7)、468-475(2006)

 

 

Polyrotaxane/DNA Conjugate by Use of Intercalation; Bridge Formation between DNA Double Helices.Kenji Tokuhsia, Emi Hamada, Ryouji Karinaga,Naohiko Shimada,Yoichi Takeda, Shinichi Kawasaki, and Kazuo Sakurai Macromolecules. 9480-9485 (2006)

 

 

 

Synthesis and in Vitro Characterization of Antigen-Conjugated Polysaccharide as a CPG DNA Carrier. Shimada, N.; Ishii, K. J.; Takeda, Y.; Coban, C.; Torii, Y.; Shinkai, S.; Akira, S.; Sakurai, Kazuo Bioconjug Chem (2006), 17, (5), 1136-1140.

 

 

Encapsulation of Ferricytochrome c into the Nanoparticle Made from a Natural Polysaccharide:  Schizophyllan. Kasuga, Mika; Shimada, Naohiko; Takeda, Yoichi; Shinkai, Seiji; Sakurai, Kazuo. Chemistry Letters (2006), 35(1), 1120-1121.

 

 

 

Galactose-PEG dual Conjugation of β-(1→3)-D-Glucan Schizophyllan for Antisense Oligonucleotides Delivery to Enhance the Cellular Uptake.Karinaga, Ryouji; Anada, Takahisa; Minari, Jusaku; Mizu, Masami; Koumoto, Kazuya; Fukuda, Junji; Nakazawa, Kohji; Hasegawa, Teruaki; Numata, Munenori; Shinkai, Seiji; Sakurai, Kazuo. Biomaterials 27(8), 1626-1635(2006)

2005年

An Enantiomeric Nanoscale Architecture Obtained from A Pseudoenantiomeric Aggregate: Covalent Fixation of Helical Chirality Formed in Self-Assembled Discotic Triazine Triamides by Chiral Amplification. Ishi-i, Tsutomu; Kuwahara, Rempei; Takata, Akihiko; Jeong, Yeonhwan; Sakurai, Kazuo; Mataka, Shuntaro. Chemistry-A European Journal (2005), 12(3), 763-776.

 

 

'Click Chemistry' on Polysaccharides: A Convenient, General, and Monitorable Approach to Delop (1,3)- b-D-Glucans with Various functional Appendages. Hasegawa, Teruaki; Umeda, Mariko; Numata, Munenori; Li, Chun; Bae, Ah-Hyun; Fujisawa, Tomohisa; Haraguchi, Shuichi; Sakurai, Kazuo; Shinkai, Seiji. Carbohydrate Research (2005), 341(1), 35-40.

 

 

Transition from a Normal to Inverted Cylinder for an Amidine-Bearing Lipid/pDNA Complex and Its Excellent Transfection. Koiwai, Kazunori; Tokuhisa, Kenji; Karinaga, Ryouji; Kudo, Yasuya; Kusuki, Shota; Takeda, Yoichi; Sakurai, Kazuo. Bioconjugate Chemistry 16(6), 1349-1351, (2005).

 

 

Oligosilane-Nanofibers Can Be Prepared through Fabrication of Permethyldecasilane within a Helical Superstructure of Schizophyllan. Haraguchi, Shuichi; Hasegawa, Teruaki; Numata, Munenori; Fujiki, Michiya; Uezu, Kazuya; Sakurai, Kazuo; Shinkai, Seiji.  Organic Letters  (2005),  7(25),  5605-5608.

 

 

Poly(diacetylene) Nanofibers Can Be Fabricated through Photo-Irradiation Using Natural Polysaccharide Schizophyllan as a One-Dimensional Mold. Hasegawa, Teruaki; Haraguchi, Shuichi; Numata, Munenori; Li, Chun; Bae, Ah-Hyun; Fujisawa, Tomohisa; Kaneko, Kenji; Sakurai, Kazuo; Shinkai, Seiji. Organic & Biomolecular Chemistry  (2005),  3(24),  4321-4328.

 

 

Water-Soluble Poly(3,4-ethylenedioxythiophene) Nanocomposites Created by a Templating Effect of β-1,3-Glucan Schizophyllan. Li, Chun; Numata, Munenori; Hasegawa, Teruaki; Fujisawa, Tomohisa; Haraguchi, Shuichi; Sakurai, Kazuo; Shinkai, Seiji. Chemistry Letters  (2005),  34(11),  1532-1533.

 

 

Water-Soluble Polythiophene as an Optical Probe for Detection of the Helicity and Conformational Transition in Polysaccharides. Li, Chun; Numata, Munenori; Hasegawa, Teruaki; Sakurai, Kazuo; Shinkai, Seiji. Chemistry Letters  (2005),  34(10),  1354-1355.

 

 

Linear Double-Stranded DNA That mimics an Infective Tail of Virus Genome to Enhance Transfection. Anada, Takahisa; Karinaga, Ryouji; Koumoto, Kazuya; Mizu, Masami; Nagasaki, Takeshi; Kato, Yoshio; Taira, Kazunari; Shinkai, Seiji; Sakurai, Kazuo. Journal of Controlled Release (2005), 108(2-3),  529-539.

 

 

Cholesterol-Appended β-(1→3)-D-Glucan Schizophyllan for Antisense Oligonucleotides Delivery to Enhance the cCellular Uptake. Koumoto, Kazuya; Mizu, Masami; Anada, Takahisa; Nagasaki, Takeshi; Shinkai, Seiji; Sakurai, Kazuo. Bulletin of the Chemical Society of Japan  (2005),  78(10),  1821-1830.

 

 

b-1,3-Glucan Polysaccharide Can Act as One-Dimensional Host to Create Novel Silica Nanofiber Structures. Numata, Munenori; Li, Chun; Bae, Ah-Hyun; Kaneko, Kenji; Sakurai, Kazuo; Shinkai, Seiji. Chemical Communications (Cambridge, United Kingdom)  (2005),   (37),  4655-4657.

 

 

Polysaccharide-Polynucleotide Complexes. Part 32. Structural Analysis of the Curdlan/Poly(cytidylic acid) Complex with Semiempirical Molecular Orbital Calculations.Miyoshi, Kentaro; Uezu, Kazuya; Sakurai, Kazuo; Shinkai, Seiji.  Biomacromolecules  (2005),  6(3),  1540-1546.

 

 

Schizophyllan Acts as a One-Dimensional Host to Accommodate 5,10,15,20-Tetrakis(4-carboxyphenyl)Porphyrinatozinc Acetate to Produce Its Fibrous Superstructure. Hasegawa, Teruaki; Fujisawa, Tomohisa; Numata, Munenori; Li, Chun; Bae, Ah-hyun; Haraguchi, Shuichi; Sakurai, Kazuo; Shinkai, Seiji. Chemistry Letters  (2005),  34(8),  1118-1119.

 

 

Transferrin-Appended β-(1→3)-D-Glucan Schizophyllan for Antisense Oligonucleotides Delivery to Enhance the Cellular Uptake. Anada, Takahisa; Karinaga, Ryouji; Mizu, Masami; Koumoto, Kazuya; Matsumoto, Takahiro; Numata, Munenori; Shinkai, Seiji; Sakurai, Kazuo. e-Journal of Surface Science and Nanotechnology  (2005),  3  195-202.

 

 

Parallel vs. Anti-Parallel Orientation in a Curdlan/Oligo(dA) Complex as Estimated by a FRET Technique. Numata, Munenori; Koumoto, Kazuya; Mizu, Masami; Sakurai, Kazuo; Shinkai, Seiji. Organic & Biomolecular Chemistry (2005), 3(12), 2255-2261.

 

 

A new Polynucleotide-polysaccharide complex and its application to functional oligonucleotide delivery. Anada, Takahisa; Sakurai, Kazuo; Shinkai, Seiji. Trends in Glycoscience and Glycotechnology (2005), 17(94), 49-57.

 

 

Poly(N-Substituted-Acrylamide)-Branched Schizophyllans are Useful for Selective Recovery of Homopolynucleotides through Convenient and Quick Precipitation Procedures. Matsumoto, Takahiro; Umeda, Mariko; Numata, Munenori; Hasegawa, Teruaki; Sakurai, Kazuo; Koumoto, Kazuya; Shinkai, Seiji. Polymer Journal (Tokyo, Japan) (2005), 37(3), 177-185.

 

 

In Situ Monitoring of Polysaccharide - Polynucleotide Interaction Using a Schizophyllan-Immobilized QCM Device. Yang, Do-Hyeon; Bae, Ah-Hyun; Koumoto, Kazuya; Lee, Seung-Woo; Sakurai, Kazuo; Shinkai, Seiji. Sensors and Actuators, B: Chemical  (2005),  B105(2),  490-494.

 

 

Competition between Polysaccharide/Polynucleotide Complexation vs. Polynucleotide Hybridization; Salt Concentration Dependence of the Reaction Direction. Karinaga, Ryouji; Koumoto, Kazuya; Minari, Jusaku; Mizu, Masami; Anada, Takahisa; Sakurai, Kazuo; Shinkai, Seiji. e-Journal of Surface Science and Nanotechnology3,(2005), 38-45.

 

 

Small-Angle X-Ray Scattering from Multi-Walled Carbon Nanotubes (CNTs) Dispersed in Polymeric Matrix. Toru Inada, Hiroyasu Masunaga, Shinichi Kawasaki, Masahiro Yamada, Kana Kobori and Kazuo Sakurai. Chem Lett.,34(4),(2005),524-525

 

 

Inclusion of Cut and As-Grown Single-Walled Carbon Nanotubes in the Helical Superstructure of Schizophyllan and Curdlan (β-1,3-Glucans) Munenori Numata, Masayoshi Asai, Kenji Kaneko,Ah-Hyun Bae,Teruaki Hasegawa, Kazuo Sakurai and Seiji Shinkai J. Am. Chem. Soc., (2005)127(16),5875-5884

 

 

Self-Assembly of Supramolecular Chiral Insulated Molecular Wire. Chun Li, Munenori Numata, Ah-Hyun Bae, Kazuo Sakurai and Seiji Shinkai. J. Am. Chem. Soc.,(2005) 127(13), 4548-4589

 

 

1D Arrangement of Au Nanoparticles by the Helical Structure of Schizophyllan: A Unique Encounter of a Natural Product with Inorganic Compounds. Ah-Hyun Bae, Munenori Numata, Teruaki Hasegawa, Chun Li, Kenji Kaneko, Kazuo Sakurai and Seiji Shinkai. Angew. Chem. Int. Ed.,44(13), 2030-2033(2005)

 

 

Small-Angle X-Ray Scattering from a Dual-Component Organogel to Exhibit a Charge Transfer Interaction. Yeonhwan Jeong, Arianna Friggeri, Isamu Akiba, Hiroyasu Masunaga, Kazuo Sakurai, Shinichi Saukai, Shigeru Okamoto, Katuski Inoue and Seiji Shinkai. J. of Colloid and Interface Science, 283,(2005), 113-122

 

 

Separation Technique for Messenger RNAs by Use of Schizophyllan/Poly(A) Tail Complexation. Taro Kimura, Akiko Beppu, Kazuo Sakurai and Seiji Shinkai. Biomacromolecules, 6, 174-179(2005)

 

 

Schizophyllan-Folate Conjugate as a New Non-Cytotoxic and Cancer-Targeted Antisense Carrier. Teruaki Hasegawa, Tomohisa Fujisawa, Shuichi Haraguchi, Munenori Numata, Ryouji Karinaga, Taro Kimura, Shiro Okumura, Kazuo Sakurai and Seiji Shinkai. Bioorg. Med. Chem. Lett.,15(2),(2005),327-330

 

 

Schizophyllan Can Act as a One-Dimensional Host to Construct Poly(diacetylene) Nanofibers. Teruaki Hasegawa, Shuichi Haraguchi, Munenori Numata, Tomohisa Fujisawa, Chun Li, Kenji Kaneko, Kazuo Sakurai and Seiji Shinkai. Chem. Lett. 34, 40-41(2005)

 

 

Inclusion of DNA into Organic Gelator Fibers Made of Amphipathic Molecules and Its Controlled Release. Karinaga, Ryouji; Jeong, Yeonhwan; Shinkai, Seiji; Kaneko, Kenji; Sakurai, Kazuo. Langmuir  21(21), 9398-9401, (2005).

 

Solvent/Gelator Interactions and Supramolecular Structure of Gel-Fibers in Cyclic Bis-Urea/Primary Alcohol Organogels. Yeonhwan Jeong, Kenji Hanabusa , Hiroyasu Masunaga , Isamu Akiba, Kentaro Miyoshi , Shinichi Sakurai and Kazuo Sakurai. Langmuir 21(2), 586-594, (2005).

 

 

 

PEG-Appended β-(1→3)-D-Glucan Schizophyllan to Dliver Antisense-Oligonucleotides with Avoiding Lysosomal Degradation. Ryouji Karinaga, Kazuya Koumoto, Masami Mizu, Takahisa Anada, Seiji Shinkai and Kazuo Sakurai. Biomaterials, 26(23), 4866-4873 (2005)

2004年

β-1,3-Glucan (Schizophyllan) Can Act as a One-Dimensional  Host for Creation of Novel Poly(aniline) Nanofiber Structures. Munenori Numata, Teruaki Hasegawa, Tomohisa Fujisawa, Kazuo Sakurai and Seiji Shinkai. Org. Lett., 6(24), 4447-4450,(2005)

 

 

Schizophyllans Carrying Oligosaccharide-Appendages as Potential Candidates for Cell-Targeted Antisense Carrier. Teruaki Hasegawa, Tomohisa Fujisawa, Munenori Numata, Takahiro Matsumoto, Mariko Umeda, Ryouji Karinaga, Masami Mizu, Kazuya Koumoto, Taro Kimura, Shiro Okumura, Kazuo Sakurai and Seiji Shinkai. Organic and biomolecular chemistry, 2, 3091-3098(2004)

 

 

Proposal of New Modification Technique for Linear Double-Stranded DNAs Using the Polysaccharide Schizopyllan. Takahisa Anada, Hideshi Matsunaga, Ryouji Karinaga, Kazuya Koumoto, Masami Mizu, Koji Nakano, Seiji Shinkai and Kazuo Sakurai. Bioorganic & Medicinal Chemistry Letters, 14, (2004),5655-5659

 

 

Single-Walled Carbon Nanotubes Acquire a Specific Lectin-Affinity through Supramolecular Wrapping with Lactose-Appended Schizophyllan. Teruaki Hasegawa, Tomohisa Fujisawa, Munenori Numata, Mariko Umeda, Takahiro Matsumoto, Taro Kimura, Shiro Okumura, Kazuo Sakurai and Seiji Shinkai. Chem. Commun, 2150-2151,(2004)

 

 

Rod-Like Architecture and Helicity of the Poly(C)/ Schizophyllan Complex Observed by AFM and SEM. H. Bae, S. W. Lee, M. Ikeda, M. Sano, S. Shinkai, K. Sakurai,. Carbohydr. Res., 339, 251-258(2004)

 

 

Chemically Modified Polysaccharide Schizophyllan for Antisense Oligonucleotides Delivery to Enhance the Cellular Uptake Efficiency. T. Matsumoto, M. Numata, T. Anada, M. Mizu, K. Koumoto, K. Sakurai, T. Nagasaki, S. Shinkai. Biochim. Biophys. Acta, 1670, 91-104 (2004)

 

 

Curdlan and Schizophyllan (β-1,3-Glucans) can Entrap Single-wall Carbon Nanotubes in Their Helical Superstructure. M. Numata, M. Asai, K. Kaneko, T. Hasegawa, N. Fujita, Y. Kitada, K. Sakurai, S. Shinkai, Chem. Lett., 33(3),232-233,(2004)

 

 

Lactose-Appended Schizophyllan is a Potential Candidate as a Hepatocyte-Targetted Antisense Carrier. T. Hasegawa, M. Umeda, T. Matsumoto, M. Numata, M. Mizu, K. Koumoto, K. Sakurai, S. Shinkai. Chem. Commun., 382-383 (2004)

 

 

Polysaccharide/Polynucleotide Complexes part 6:Complementary-Strand-Induced Release of Single-stranded DNA Bound in the Schizophyllan Complex. K. Koumoto, M. Mizu, K. Sakurai, T. Kunitake, S. Shinkai. Chemistry & Biodiversity, 1, (2004),520-529

 

 

Enhancement of the Antisense Effect of Polysaccharide-Polynucleotide Complexes by Preventing the Antisense Oligonucleotide from Binding to Proteins in the Culture Medium. M. Mizu, K. Koumoto, T. Anada, R. Karinaga, T. Kimura, T. Nagasaki, S. Shinkai, K. Sakurai. Bull. Chem. Soc. Jpn., (2004),77, 1101-1110  

 

 

First Observation by Fluorescence Polarization of Complexation between mRNA and the Natural Polysaccharide Schizophyllan . R. Karinaga, M. Mizu, K. Koumoto, T. Anada, S. Shinkai, T. Kimura, K. Sakurai. Chemistry & Biodiversity, 1, 634-639 (2004)

 

 

Removal of the Side-Chain Glucose Groups from Schizophyllan Improves the Thermal Stability of the Polycytidylic Acid Complexes under the Physiological Conditions. K. Koumoto, R. Karinaga, M. Mizu, T. Anada, K. Sakurai, T. Kunitake, S. Shinkai. Biopolymers, 75, 403-411(2004)

 

 

Lactose-Appended Schizophyllan is a Potential Candidate as a Hepatocyte-Targetted Antisense Carrier. Teruaki Hasegawa, Mariko Umeda, Takahiro Matsumoto, Munenori Numata, Masami Mizu, Kazuya Koumoto, Kazuo Sakurai and Seiji Shinkai. Chem. Commun.,382-383(2004)

 

 

Complementary-Strand-Induced Release of Single-Stranded DNA Bound in the Schizophyllan Complex. Kazuya Koumoto, Masami Mizu, Kazuo Sakurai, Toyoki Kunitake and Seiji Shinkai. Chemistry & Biodiversity,1, 520-529,(2004)

 

 

Protection of Polynucleotides against Nuclease-Mediated Hydrolysis by Complexation with Schizophyllan. M. Mizu, K. Koumoto, T. Kimura, K. Sakurai, S. Shinkai. Biomaterials  25, 3109-3116, (2004).

 

 

 

A Polysaccharide Carrier for Immunostimulatory CpG DNAs to Enhance Cytokine Secretion. M. Mizu, K. Koumoto, T. Anada, T. Matsumoto, M. Numata, S. Shinkai, T. Nagasaki, K. Sakurai. J. Am. Chem. Soc.  126, 8372-8373, (2004).

2003年

Mechanism of Thermally Induced Morphological Reorganization and Lamellar Orientation from the Herringbone Structure in Cross-Linked Polystyrene-Block-Polybutadiene-Block-Polystyrene Triblock Copolymers. S. Sakurai, S. Aida, S. Okamoto, K. Sakurai, S. Nomura. Macromolecules, 36(6), (2003),1930-1939

 

 

Mesomorphic Organization and Phase Diagram of Mixtures of Polymer Terminated with Ionic Group and Oppositely Charged Surfactant. I.Akiba,Y.Jeong,K.Sakurai, Macromolecules, 36, (2003),8433-8439

 

 

Microanalysis of Nucleic Acids Using the Limulus G Test. T. Anada, K. Koumoto, M. Mizu, R. Karinaga, K. Sakurai, S. Shinkai. Anal. Sci., 19, 1567-1568(2003)

 

 

Polysaccharide-Polynucleotide Complexes (15): Thermal Stability of Schizophyllan (SPG)/poly(C) Triple Strands is Controllable by α-amino Acid Modification. M. Numata, T. Matsumoto, M. Umeda, K. Koumoto, K. Sakurai, S. Shinkai. Bioorg. Chem., 31,(2003),163-171

 

 

Polysaccharide-Polynucleotide complexes Part 17. Solvent Effects on Conformational-Transition of polydeoxyadenylic Acid in the Complex with Schizophyllan. M. Mizu, K. Koumoto, T. Kimura, K. Sakurai, S. Shinkai. Polym. J., 35, 714-720,(2003)

 

 

Polysaccharide-Polynucleotide Complexes Part 7. Hydrogen-Ion and Salt Concentration Dependence of Complexation between Schizophyllan and Single-Stranded Homo RNAs. K. Sakurai, R. Iguchi, M. Mizu, K. Koumoto, S. Shinkai. Bioorg. Chem., 31, 216-226(2003)

 

 

Spherulite Formation from Microphase-Separated Lamellae in Semi-Crystalline Diblock Copolymer Comprising Polyethylene and Atactic Polypropylene Blocks. M. Ueda, K. Sakurai, S. Okamoto, D. J. Lohse, W. J. MacKnight, S. Shinkai, S. Sakurai, S. Nomura, Polymer, 44(2003), 6995-7005

 

 

 

Supramolecular Structure of a Sugar-Appended Organogelator Explored with Synchrotron X-ray Small -Angle Scattering. K. Sakurai, Y. Jeong, K. Koumoto, A. Friggeri, O. Friggeri, O. Gronwald, S. Sakurai, S. Okamoto, K. Inoue, S. Shinkai. Langmuir 19, 8211-8217, (2003).

2002年

Polysaccharide-Polynucleotide Complexes Ⅷ. Cation Induced Complex Formation Between Polyuridylic Acid and Schizophyllan. K. Sakurai, R. Iguchi, K. Koumoto, T. Kimura, M. Mizu, Y. Hisaeda, S. Shinkai. Biopolymers, 65, 1-9,(2002)

 

 

Some Anomalies in Pressure-Induced Ordering of Glassy Spheres in a Rubbery Matrix of a Microphase-Separated Triblock Copolymers. S. Sakurai, S. Aida, T. Tamura, T. Kota, S. Okamoto, K. Sakurai, N. Tanaka, S. Kunugi, S. Nomura. Polymer, 43,(2002), 1959-1962

 

 

Polysaccharide-Polynucleotide Complexes Part 12: Enhanced Affinity for Various Polynucleotide Chains by Site-Specific Chemical Modification of Schizophyllan. K. Koumoto, T. Kimura, M. Mizu, T. Kunitake, K. Sakurai, S. Shinkai. J. Chem. Soc, Perkin Trans. 1, 2477-2484(2002)

 

 

Polysaccharide-Polynucleotide Interaction(Ⅺ);Novel Separation System of RNAs by Using Schizophyllan-Appended Column. T. Kimura, K. Koumoto, M. Mizu, K. Sakurai, S. Shinkai. Chem Lett., 1240-1241(2002)

 

 

Novel DNA-Polysaccharide Triple Helix and its Application to a Gene Carrier. K. Sakurai, K. Koumoto, M. Mizu, S. Shinkai. Am. Chem. Soc. Polym. Prep., 43, 691-692,(2002)

 

 

Chemical Modification of Curdlan: Characteristic Complexation with Polynucleotides by Control of The Molecular Weight. K. Koumoto, K. Sakurai, S. Shinkai, T. Kunitake. Am. Chem. Soc. Polym. Prep., 43,721-723,(2002)

 

 

Self-Organized Structures of Hydrogen Bonded Poly(4-vinylphenol)-Tertiary Amino Lipid Mixtures. I.Akiba, K. Sakurai. e-Polymers, 53, (2002),1-6

2001年

Complementary polynucleotide mimic behavior of a Natural polysaccharide: Schizophyllan in the Macromolecular Complex with a Single stranded RNA: Poly(C). K. Sakurai, M. Mizu, S. Shinkai. Biomacromolecules, 2, 641-650,(2001)

 

 

Thermally Induced Conformational-Transition of Polydeoxyadenosine in the Complex with Schizophyllan and the Base-Length Dependence of Its Stability. M. Mizu, T. Kimura, K. Koumoto, K. Sakurai, S. Shinkai. Chem. Commun., 429-430(2001)

 

 

Structural Analysis on Aggregates of Graft Copolymers Containing Tryptophan in Aqueous Media and Efficiency of Drug Release Structure and properties of polymer materials. S. Okamoto, T. Hanai, F. Yamauchi, K. Nagata, S. Sakurai, K. Sakurai, E. Nakanishi. Material Science Research International, 7, 219-224,(2001)

 

 

A Hexagonally Organizes Elemental Supramolecular Structure of a Sugar-Appended Organogelator  Observed by Synchrotron X-Ray Source (SPring-8). K. Sakurai, T. Kimura, O. Gronwald, K. Inoue, S. Shinkai. Chem. Lett.,(2001),746-747

 

 

Further Evidence for the Gelation    Ability-Structure Correlation in Suger-Based Gelators. O.Gronwald, K. Sakurai, R. Luboradzki, T. Kimura, S. Shinkai. Carbohydrate Res., 331,(2001), 307-318

 

 

Synchrotron Small Angle X-ray Scattering from Organogels. Part 1. Changes in Molecular Assemblies of Cholesterol Gelators during Gel-Sol transition. K. Sakurai, Y. Ono, J. H. Jung, S. Okamoto, S. Sakurai, S. Shinkai. J. Chem.Soc., Perkin Trans.2,(2001),108-112

 

 

Novel DNA-Polysaccharide Triple Helixes and Their Application to a Gene Carrier. K. Sakurai, S. Shinkai. J. Inclusion Phenomena and macrocyclic chemistry, 41(1-4),173-178,(2001)

 

 

Chemical Modification of Schizophyllan by Introduction of a Cationic Charge into the Side Chain which Enhances the Thermal Stability of Schizophyllan-Poly(C) Complexes. K. Koumoto, T. Kimura, M. Mizu, K. Sakurai, S. Shinkai. Chem. Commun.,1962-1963(2001)

 

 

Chemical Modification of Curdlan to Induce an Interaction with Poly(C). K. Koumoto, T. Kimura, H. Kobayashi, K. Sakurai, S. Shinkai. Chem. Lett., 908-909(2001)

 

 

Polysaccharide-Polynucleotide Complexes(Ⅳ): Antihydrolysis Effect of the Schizophyllan/Poly(C) Complex and the Cmplex Dissociation Induced by Amines. K. Koumoto, T. Kimura, K. Sakurai, S. Shinkai. Bioorg. Chem., 29, 178-185,(2001)

2000年

Molecular Recognition of Adenine , Cytosine , and Uracil in a Single-Stranded RNA by a Natural Polysaccharide : Schizophyllan. K. Sakurai, S. Shinkai. J. Am. Chem. Soc,(2000), 122, 4520-4521

 

 

Novel Vesicular Aggregates of Crown-Appended Cholesterol Derivatives Which Act as Gelators of Organic Solvents and as Templates for Silica Transcription. J. H. Jung, Y. Ono, K. Sakurai, M. Sano, S. Shinkai. J. Am. Chem. Soc.,(2000), 122,8648-8653

 

 

Preferential Orientation of the Crystallite Spatially Confined in the Lamella Microdomain of Polyethylene-B-Atactic Polypropylene. K. Sakurai, S. Shinkai, M. Ueda, S. Sakurai, S. Nomura, W. J. MacKnight, D. L. Lohse. Macro. Rapid Commun., 16, 1140-1143,(2000)

 

 

Optical Properties of a Low Birefringence Polyester Containing Fluorene Side Chain. K. Sakurai, M. Fuji. Polymer J., 32(8), 676-682,(2000)

 

 

Viscoelasticity and Birefringence of Low Birefringence Polyester. T. Inoue, K. Fujikawa, Deug-Soo RYU, K. Osaki, M. Fuji, K. Sakurai. Polymer J., 32(5), 411-414,(2000)

 

 

Phase Separation in the Mixture of Schizophyllan and Poly(ethylene oxide) in Aqueous Solution Driven by a Specific Interaction between the Glucose Side Chain and Poly(ethylene oxide). K. Sakurai, S. Shinkai. Carbohydrate Research, 324, 136-140,(2000)

1999年

Preparation of NanoParticles Consisted of Poly(L-lactide)-Poly(Ethylene Glycol)-Poly(L-Lactide)and Their Evaluation in Vitro. J. Matsumoto, Y. Nakada, K. Sakurai, T. Nakamura, Y. Takahashi. International Journal of Pharmaceutics, 185, 93-101,(1999)

 

Preparation and Polylactide-Poly(Ethylene Glycol)- Polylactide Triblock Polymers and a Preliminary in Vivo Examination of THe Blood Circulation Time for The Nanoparticles Made Therefrom. K. Sakurai, Y. Nakada, J. Matsumoto, T. Nakamura, Y. Takahashi. J. Macromolecular Sci. Pure and Applied Chemistry, A36(12), 1863-1877,(1999)

1998年

Evaluation of Long-Circulating Nanoparticles Using Biodegradable ABA Triblock Copolymers Containing of Poly(L-Lactic Acid)A-Blocks Attached to Central Poly(Oxyethylene)B-Blocks in Vivo. Y. Nakada, R. Tudomi,K. Sakurai,  Y. Takahashi. International Journal of Pharmaceutics, 175, 109-117,(1998)

1997年

Long-circulating Nano-particles Using Biodegradable ABA Triblock Copolymers Containing Poly(L-lactide)A-blocks attached to Central Poly(oxyethylene) B-blocks
Y. Nakada, K. Sakurai, M. Horiuchi, R. T. Nakamura, Y. Takahashi, Pharmaceutical Science, 3 ,479-482

 

光学用ポリエステル樹脂
櫻井和朗, 合成樹脂, 43, 14-16

 

近赤外線吸収フィルム
櫻井和朗,「近赤外線の応用」近畿化学会機能性色素部会報告, 37, 21-22

 

光学用ポリエステル樹脂
櫻井和朗, 藤通昭, コンバーテック, 25, 1-7

1996年

Dynamic Viscoelastic Properties of Poly(Ethylene-Propylene) Diblock Copolymer in the Melt State and Solutions. K. Sakurai, D. J. Lohse, D. N. Schulz, J. A. Sissano, W. J. MacKnight, W. Welder, H. Winter. Polymer, 37(23), 5159-5163,(1996)

 

 

Blends of Amorphous-Crystalline Block Copolymers with Amorphous Homopolymers. Morphological Studies by Electron Microscopy and Small Angle Scattering. K. Sakurai, D. J. Lohse, D. N. Schulz, J. A. Sissano, W. J. MacKnight, J-S.Lin, M. Agamalyan, Polymer, 37(20),4443-4453,(1996)

1994年

Blends of Amorphous-Crystalline Block Copolymers with Amorphous Homopolymers.2.Synthesis and Characterization of Poly(Ethylene-Propylene) Diblock Copolymer and Crystallization Kinetics for the Blend with Atactic Polypropylene. K. Sakurai, W. J. MacKnight, D. J.Lohse, D. N. Schulz, J. A. Sissano. Macromolecules, 27, 4941-4951,(1994)

1993年

Spectroscopic Study of Zinc Neutralized Sulfonated Polystyrenes and Blends with Poly[ethyl acrylate-co-(4-vinylpyridine)]. K. Sakurai, E. Douglas, W. J. MacKnight. Macromolecules, 26, 208-212,(1993)

 

 

Clustering Phenomena in Ionomeric Blends. E. P. Douglas, K. Sakurai, W. J. MacKnight, Polymer Preprints,American Chemical Society, 33, 587-588,(1993)

 

 

 

Amorphous-Crystalline Block Copolymer and Amorphous Homopolymer Blends. 1.A Preliminary Report. K. Sakurai, W. J. MacKnight, D. J. Lohse, D. N. Schulz, J. A. Sissano, Macromolecules, 26(12), 3236-3238,(1993)

 

 

Blends of Amorphous-Crystalline Block Copolymers with Amorphous Homopolymers: Small-Angle Scattering Studies. K. Sakurai, D. J. Lohse, D. N. Schulz, J. A. Sissano, W. J. MacKnight, Polymer Preprints,American Chemical Society, 34, 587,(1993)

1992年

Spectroscopic Study of an Ionic Blend Made from the Acid Form of Sulfonated Polystyrene and Poly[ethyl acrylate-co-(4-vinylpyridine)]. K. Sakurai, E. P. Douglas, W. J. MacKnight, Macromolecuies, 25, 4506-4510,(1992)

1991年

Thermal Analysis and Optical Microscopy of Modified Polystyrene/Poly(ethyl acrylate) Blends Containing Specific Interactions. E. P. Douglas, K. Sakurai, W. J. MacKnight. Macromolecuies, 24, 6776-6781,(1991)

1990年

A Study of Porous Polyacenic Semiconductors Toward an Application Ⅲ. Characteristics of Practical Batteries Employing Polyacenic Semiconductive Materials as the Electrodes. S. Yata, K. Sakurai, T. Osaki, Y. Inoue, K. Yamaguchi, T. Tanaka, T. Yamabe, Synthetic Metals, 38, 185-191, (1990)

1988年

Porous Article Having Open Pores Prepared from Aromatic Condensation Polymers and Use Thereof
S. Yata, Y. Hato, T. Osaki, K. Sakurai, US Patent, 4753717

1987年

A Polymer Battery Employing Polyacenic Semiconductors. S. Yata, Y. Hato, K. Sakurai, T. Osaki, T. Tanaka, T. Yamabe, Synthetic Metals, 18, 645-651,(1987)

 

1984年

Stiff-Chain Behavior of Poly(terephthalamide-p-benzohydrazide) in Dimethyl Sulfoxide. K. Sakurai, K. Ochi, T. Norisuye, H. Fujita, Polymer. J., 16(7), 559-567,(1984)

1983年

Collapse of Randomly Coiled Schizophyllan in Mixture of Water and Dimethylsulfoxide. T. Sato, K. Sakurai, T. Norisuye, H. Fujita, Polymer. J., 15(1), 87-92,(1983)

その他の著作物(総説、書籍など)

宮本寛子, 望月慎一, 櫻井和朗「多糖β-1,3-グルカンの受容体を利用したオリゴ核酸の選択的デリバリー」Cellulose Commun. Research Trends 3 Vol.19, No. 1, (2012)P12-16

 

 

櫻井和朗、望月慎一「β-1,3-グルカン/DNA複合体の性質と核酸医薬DDSへの応用」先端バイオマテリアルハンドブックp378-384  2012年6月15日 株式会社エヌ・ティー・エス 刊

 

 

櫻井和朗「自己組織化した分子会合体の溶液物性:分子描像の可視化へのこころみ」高分子61巻10月号 高分子科学最近の進歩 P787-790(2012年)

 

 

日経バイオテク9月号SELECTED NEWSで特に重要なニュースということで掲載「siRNAベンチャーの米NapaJen社、CD40標的薬の動物実験で好結果、九大・北九州市大の研究成果応用」

 

 

櫻井和朗 「歴史の転換点2011年と繊維科学」繊維学会誌FIBER 繊維と工業 7月号Vol.67, No.7,P169(2011)

 

 

望月慎一、櫻井和朗 「糖鎖を利用した核酸医薬の選択的デリバリー」 医学のあゆみ RNA医学・医療-あらたな診断・治療を拓く Vol.238, No.5, P441-446, (7/30 2011)

 

 

望月慎一、櫻井和朗 「アジュバント開発研究の新展開 第3章アジュバント各論2.8 -βグルカンを利用した次世代型アジュバント開発研究の新展開-」(2011.8.24)シーエムシー出版

 

 

櫻井和朗 「薬物送達システム」を実現するナノ粒子の正体を解明する SPring-8学術成果集 夢の光を使ってサイエンスの謎に挑む Topic8, 25-26(2010)

 

 

櫻井和朗 「長期利用課題報告2 超分子化学と放射光小角散乱」 SPring-8利用者情報 Vol.15, No.2, 59-63(5月,2010)

 

 

櫻井和朗 「フロンティアソフトマター開発産学連合ビームライン(FSBL):BL03XUの概要」 SPring-8利用者情報 Vol.15, No.2, 69-74(5月,2010)

 

 

櫻井和朗 「先端光源を用いたソフトマテリアルに関する国際会議をSPring-8で開催」 SPring-8利用者情報 Vol.15, No.4, 275-277(11月,2010)

 

 

櫻井和朗 「β-1,3-グルカンと核酸複合体の性質と機能」 βグルカンの基礎と応用 Basic and Applied Sciences of β-glucan 57-73, 2010,9,30

 

 

櫻井和朗 「多糖-核酸複合体とその応用」 超分子サイエンス&テクノロジー 1058-1066, 2009,5,15

 

 

望月慎一・櫻井和朗「多糖β-1,3グルカンの受容体を利用したオリゴ核酸の選択的デリバリー」 Drug Delivery System Vol.25, No.6, 565-572, November 2010

 

 

Kazuo Sakurai「Small-Angle X-Ray Scattering from Drug Delivering Nanoparticles in Solutions:Pharmacological Efficiency and Particle-Inner Structures」SPring-8 Research Frontiers 2009 CHEMICAL SCIENCE,96-97(2010)

 

 

杉原保則、櫻井和朗「BL03XUフロンティアソフトマター開発産学連合ビームライン」SPring-8年報2009年度 大型放射光施設の現状と高度化,143-144(2010)

 

 

杉原保則、中尾俊夫、櫻井和朗、増永啓康、小川紘樹、高野琢「大型放射光施設「SPring-8」を活用した新規高分子材料の開発」月刊Polyfile 12月号 特集 高分子材料2010年の動向と2011年への期待,21-25(2010,12,20)

 

 

櫻井 和朗「β-1,3-グルカンと核酸複合体の性質と機能」βグルカンの基礎と応用 第7章(CMC出版)大野尚仁

 

 

櫻井 和朗「超分子化学と放射光小角散乱」SPring-8 利用者情報誌 Vol. 15 p59 2010

 

 

杉原保則、櫻井 和朗、増永啓康、小川紘樹「フロンティアソフトマター開発ビームライ(FSBL):BL03XUの概要」SPring-8 利用者情報誌 Vol. 15 p64 2010

 

 

岡田 明彦, 櫻井 和朗「新繊維素材開発のためのSPring8ビームライン建設 」繊維学会誌, Vol. 64 No. 5, 153-155, 2008

 

 

K. Sakurai and S. Shinkai「An Oligonucleotide Carrier Based on β-1,3-Glucan」Non-viral Gene Therapy: Gene Design and Derivery, 2005

 

 

S. Sakurai, S. Okamoto, and K. Sakurai「Melt Behaviour of Block Copolymers (Chapter 4)」Developments in Block Copolymer Science and Technology, Wiley 2004

 

 

Kazuo Sakurai「Small-Angle X-Ray Scattering from Self-assembled Aggregates that form Rod-like Architecture.」2004年SPring-8報告書

 

 

Kazuo Sakurai, Kazuya Koumoto, and Seiji Shinkai$「A Novel Triple Helix Consisting of One Polynucleotide and Two Polysaccharide Chains」 Macromolecular Nanostructured Materials, Kodanasha&Ppringer Edited by N. Ueyama and A. Harada, 2004

 

 

K. Sakurai, D. J. Lohse, D. N. Schulz, J. A. Sissano, M. Y. Lin, M. Agamalyan, and W. J. MacKnight「Crystallization Kinetics and Microdomain Structures for the Blends of Amorphous-Crystalline Block Copolymers with Amorphous Homopolymers」Ordering in Macromolecular Systems, Springer-Verlag, 1993

 

 

藤 通昭・櫻井和朗・藤田昭秀「光学用ポリエステル樹脂」透明ポリマーの屈折率制御(化学総説No39) 1998年→透明ポリマーの屈折率制御は論文には全く記載無し

 

 

櫻井 和朗 新海 征治「多糖β-1,3-グルカンと核酸からなる複合体の性質と核酸医薬DDSへの応用」その1:多糖・核酸複合体の発見まで、「アンチセンス」2006年

 

 

b-1,3-Glucan Polysaccharides as Novel One-Dimensional Hosts for DNA/RNA, Conjugated Polymers and Nanoparticles Sakurai, Kazuo; Uezu, Kazuya; Numata, Munenori; Hasegawa, Teruaki; Li, Chun; Kaneko, Kenji; Shinkai, Seiji. Chemical Communications  (Cambridge, United Kingdom) (35), 4383-4398, (2005).

 

 

狩長亮二、甲元一也、櫻井和朗、新海征治「多糖・核酸複合体を用いた機能性高分子コンジュゲート-核酸医薬デリバリーへの挑戦-」高分子加工、53(12)、561-568 (2004)

 

 

櫻井和朗、新海征治「多糖・核酸からなる3重らせんの発見とその応用」高分子、51(8) (2002)

 

 

甲元一也、水雅美、櫻井和朗、新海征治「アンチセンス治療へ向けた多糖系遺伝子キャリアー」月刊BIOINDUSTRY, 20, 30-37 (2003)

 

 

木村太郎、櫻井和朗、新海征治「多糖シゾフィランを利用した核酸の分離精製」高分子加工, 52, 9-14 (2003)

 

 

櫻井和朗, 新海征治,「多糖・核酸からなる3重らせんの発見とその応用」高分子, 51, 603-606 (2002)

 

 

櫻井和朗,「光学用ポリエステル樹脂合成樹脂, 43, 14-16 (1997)」近赤外線吸収フィルム

 

 

櫻井和朗,「近赤外線の応用」近畿化学会機能性色素部会報告, 37, 21-22(1997)

 

 

櫻井和朗, 藤通昭,「光学用ポリエステル樹脂」コンバーテック, 25, 1-7(1997)

 

 

櫻井和朗,「光学用プラスチック光学用ポリエステル樹脂」ペトロティック, 19, 536-543(1996)

 

 

櫻井和朗,「光学用ポリエステル樹脂」プラスチックエージ, 42, 132-133(1996)

 

 

八百健二, 五十嵐光永, 藤通昭, 久保美奈, 櫻井和朗, 堀川幸夫,「光学用ポリエステル樹脂」機能材料,14, 5-12(1994)

特許

US Patents

United States Patent 6.255.031 2001
Yao, K.; Koike, M,; Suzuki, Y.; Sakurai, K.; Indo, T.; Igarashi, K

 

United States Patent 6.066.711 2000
Hnazawa, M.; Sakurai, K.; Yao, K.

 

United States Patent 4.753.717 1988
Yata, S.; Hato, Y.; Osaki, T.; Sakurai, K.

2017年

出願番号;特願2017-068276

発明者;望月慎一、森下博美、櫻井和朗

発明の名称;免疫誘導剤及びそれを含む医薬組成物

出願人;公立大学法人北九州市立大学

 

2016年

公開番号:特開2016-113404(特願2014-253763)

発明者;櫻井和朗、望月慎一

発明の名称;ポリヌクレオチド/シゾフィラン複合体及びそれを含む医薬 組成物

 

2015年

出願番号;特願2015-561185

発明者;櫻井和朗、望月慎一、森下博美

発明の名称;ペプチド/b-1,3-グルカン複合体及びそれを含む医薬組成物

出願人;独立行政法人科学技術振興機構

 

2014年

出願番号;特願2014-521495

発明者;櫻井和朗、望月慎一、田中素子、樋口貞春

発明の名称;核酸複合体および核酸多糖複合体

出願人;独立行政法人科学技術振興機構

 

2011年

公開番号;特開2011-178707(特願2010-043592)

発明者;櫻井和朗、望月慎一、松崎翼

発明の名称;b -1,3-グルカン/核酸複合体の調製方法

出願人;独立行政法人科学技術振興機構

 

2010年

公開番号;特開2010-207109(特願2009-054249)

発明者;西平順、小山芳一、櫻井和朗、望月慎一、光山慶一、竹田津英稔、

武田宏司、藤山佳秀、安藤朗

発明の名称;炎症性腸疾患の治療剤及びそれに用いられるポリヌクレオチ

出願人;財団法人北九州産業学術推進機構

 

公開番号;特開2010-174107(特願2009-017093)

発明者;櫻井和朗、望月慎一、寺田直隆

発明の名称;三元複合体の製造方法及び抗原たんぱく質/CpGオリゴヌクレオチド/b-1,3-グルカン系三元複合体

出願人;財団法人北九州産業学術推進機構

 

2003年

遺伝子キャリヤー
特願2001-536203

 

マトリックスとの結合サイトを有する多糖
特開2003-137904(特願2001-339199)

 

核酸分離剤
特開2003-035704(特願2001-357095)

2002年

近赤外線吸収フィルム及び当該フィルムを含む多層パネル
特開2002-082219(特願2001-172109)

2000年

光学素子
特開2000-119379(特願平10-296571)

 

ポリエステル重合体およびその成形体
特開2000-044662(特願平10-218865)

1999年

透明な高分子と複数の色素を含むフィルム及び当該フィルムを含む多層フィルム又はパネル
特開平11-116826(特願平09-297697)

 

プラズマディスプレイ用前面多層パネル
特開平11-073115(特願平09-236103)

1997年

近赤外線吸収フィルム及び当該フィルムを含む多層パネル
特願平09-536962

 

近赤外線吸収パネル
特開平09-330612(特願平08-168231)

 

ポリエステル重合体およびその成形体
特開平09-302077(特願平08-148447)

微粒子製剤
特開平09-208494(特願平08-334839)

 

ポリ乳酸-ポリエチレングリコール-ポリ乳酸三元ブロック共重合体の精製方法
特開平09-157368(特願平07-338123)

 

液晶ディスプレイのフィルムシート用ポリエステル重合体
特開平09-157367(特願平07-345582)

1996年

電子写真感光体バインダー用ポリエステル樹脂
特開平08-334907(特願平07-164728)

 

電子写真感光体バインダー用ポリエステル樹脂
特開平08-314162(特願平07-145414)

電子写真感光体バインダー用ポリエステル樹脂
特開平08-211633(特願平07-145413)

 

電子写真感光体バインダー用ポリエステル樹脂
特開平08-211632(特願平07-145412)

ポリエステル重合体
特開平08-188644(特願平07-216806)

 

電子写真感光体バインダー用ポリエステル樹脂
特開平08-152722(特願平06-321403)

ポリエステルフィルムおよびその製造方法
特開平08-134192(特願平06-303205)

 

高分子量ポリエステル樹脂及びその製造方法
特開平08-109249(特願平06-272968)

ポリエステル重合体およびその成形体
特開平08-100053(特願平07-216807)

1995年

プラスチックレンズ用ポリエステル樹脂
特開平07-198901(特願平05-351934)

 

ポリエステル重合体及びその成形体
特開平07-188401(特願平05-351933)

 

ポリエステル重合体
特開平07-149881(特願平06-024787)